Reprogramming the Epigenome With Vitamin C

被引：88
作者：
Chong, Taylor Lee [1 ]
Ahearn, Emily L. [1 ]
Cimmino, Luisa [1 ,2 ]
机构：
[1] Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, Miami, FL 33136 USA
[2] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2019年 / 7卷
关键词：
vitamin C; stem cell reprogramming; TET; Jumonji C; cancer; PLURIPOTENT STEM-CELLS; HYPOXIA-INDUCIBLE FACTORS; ACUTE MYELOID-LEUKEMIA; ASCORBIC-ACID; DNA METHYLATION; GENE-EXPRESSION; HISTONE DEMETHYLASES; COLLAGEN-SYNTHESIS; TET PROTEINS; PHARMACOLOGICAL ASCORBATE;
D O I：
10.3389/fcell.2019.00128
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin C plays a pivotal role in remodeling the epigenome by enhancing the activity of Jumonji-C domain-containing histone demethylases (JHDMs) and the ten-eleven translocation (TET) proteins. By maintaining differentiation plasticity in culture, vitamin C also improves the quality of tissue specific stem cells derived from iPSCs that are highly sought after for use in regenerative medicine. The ability of vitamin C to potentiate the activity of histone and DNA demethylating enzymes also has clinical application in the treatment of cancer. Vitamin C deficiency has been widely reported in cancer patients and has recently been shown to accelerate cancer progression in disease models. Therapies involving high-dose vitamin C administration are currently gaining traction in the treatment of epigenetic dysregulation, by targeting aberrant histone and DNA methylation patterns associated with cancer progression.
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页数：13
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共 149 条
[81]   Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration [J].
Mandai, M. ;
Watanabe, A. ;
Kurimoto, Y. ;
Hirami, Y. ;
Morinaga, C. ;
Daimon, T. ;
Fujihara, M. ;
Akimaru, H. ;
Sakai, N. ;
Shibata, Y. ;
Terada, M. ;
Nomiya, Y. ;
Tanishima, S. ;
Nakamura, M. ;
Kamao, H. ;
Sugita, S. ;
Onishi, A. ;
Ito, T. ;
Fujita, K. ;
Kawamata, S. ;
Go, M. J. ;
Shinohara, C. ;
Hata, K. ;
Sawada, M. ;
Yamamoto, M. ;
Ohta, S. ;
Ohara, Y. ;
Yoshida, K. ;
Kuwahara, J. ;
Kitano, Y. ;
Amano, N. ;
Umekage, M. ;
Kitaoka, F. ;
Tanaka, A. ;
Okada, C. ;
Takasu, N. ;
Ogawa, S. ;
Yamanaka, S. ;
Takahashi, M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (11) :1038-1046
[82]   Vitamin C: update on physiology and pharmacology [J].
Mandl, J. ;
Szarka, A. ;
Banhegyi, G. .
BRITISH JOURNAL OF PHARMACOLOGY, 2009, 157 (07) :1097-1110
[83]   The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming [J].
Mansour, Abed AlFatah ;
Gafni, Ohad ;
Weinberger, Leehee ;
Zviran, Asaf ;
Ayyash, Muneef ;
Rais, Yoach ;
Krupalnik, Vladislav ;
Zerbib, Mirie ;
Amann-Zalcenstein, Daniela ;
Maza, Itay ;
Geula, Shay ;
Viukov, Sergey ;
Holtzman, Liad ;
Pribluda, Ariel ;
Canaani, Eli ;
Horn-Saban, Shirley ;
Amit, Ido ;
Novershtern, Noa ;
Hanna, Jacob H. .
NATURE, 2012, 488 (7411) :409-+
[84]   A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity [J].
Marion, Rosa M. ;
Strati, Katerina ;
Li, Han ;
Murga, Matilde ;
Blanco, Raquel ;
Ortega, Sagrario ;
Fernandez-Capetillo, Oscar ;
Serrano, Manuel ;
Blasco, Maria A. .
NATURE, 2009, 460 (7259) :1149-1153
[85]   Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency [J].
Mathieu, Julie ;
Zhou, Wenyu ;
Xing, Yalan ;
Sperber, Henrik ;
Ferreccio, Amy ;
Agoston, Zsuzsa ;
Kuppusamy, Kavitha T. ;
Moon, Randall T. ;
Ruohola-Baker, Hannele .
CELL STEM CELL, 2014, 14 (05) :592-605
[86]   Vitamin C deficiency in cancer patients [J].
Mayland, CR ;
Bennett, MI ;
Allan, K .
PALLIATIVE MEDICINE, 2005, 19 (01) :17-20
[87]   Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia [J].
Mingay, M. ;
Chaturvedi, A. ;
Bilenky, M. ;
Cao, Q. ;
Jackson, L. ;
Hui, T. ;
Moksa, M. ;
Heravi-Moussavi, A. ;
Humphries, R. K. ;
Heuser, M. ;
Hirst, M. .
LEUKEMIA, 2018, 32 (01) :11-20
[88]   Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine [J].
Minor, Emily A. ;
Court, Brenda L. ;
Young, Juan I. ;
Wang, Gaofeng .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (19) :13669-13674
[89]   Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche [J].
Mohyeldin, Ahmed ;
Garzon-Muvdi, Tomas ;
Quinones-Hinojosa, Alfredo .
CELL STEM CELL, 2010, 7 (02) :150-161
[90]   Breathing-in epigenetic change with vitamin C [J].
Monfort, Asun ;
Wutz, Anton .
EMBO REPORTS, 2013, 14 (04) :337-346
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