Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids

被引：21

作者：

Song, Yang ^{[1
,2
]}

Wang, Mingming ^{[1
]}

Akkineni, Susrut ^{[1
]}

Yang, Wenchao ^{[1
]}

Hettige, Jeevapani J. ^{[1
]}

Jin, Haibao ^{[1
]}

Liao, Zhihao ^{[1
]}

Mu, Peng ^{[1
,3
,4
]}

Yan, Feng ^{[1
,5
]}

Baer, Marcel ^{[1
]}

De Yoreo, James J. ^{[1
]}

Du, Dan ^{[2
]}

Lin, Yuehe ^{[2
]}

Chen, Chun-Long ^{[1
,6
]}

机构：

[1] Pacific Northwest Natl Lab, Div Phys Sci, Richland, WA 99352 USA

[2] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA

[3] SUNY Binghamton, Dept Mech Engn, Binghamton, NY 13902 USA

[4] SUNY Binghamton, Mat Sci & Engn Program, Binghamton, NY 13902 USA

[5] Linyi Univ, Coll Chem & Chem Engn, Linyi 276005, Shandong, Peoples R China

[6] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

来源：

ACS MATERIALS LETTERS | 2021年 / 3卷 / 04期

关键词：

MOLECULAR PACKING; POLYMERS; EMISSION; NANOPARTICLES; MICROSCOPY; CRYSTALS; DESIGN; DYE;

D O I：

10.1021/acsmaterialslett.1c00110

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Free-standing two-dimensional (2D) organic nanomaterials are highly attractive for biological applications because of their unique structural properties and high biocompatibility. Herein, we designed and synthesized a new class of highly bright and photostable membrane-mimetic 2D nanosheets from sequence-defined peptoids. These nanosheets exhibited high quantum yield and photostability as a result of the precise placement and ordering of dansyl dye molecules within crystalline nanosheets. We further showed the use of these nanosheets as biocompatible and programmable probes for live cell imaging and cell labeling. By programing these nanosheets with different surface charges, we achieved the enhanced lysosome escape of these nanosheets, showing their great potential as nanocarriers for the efficient intracellular delivery of macromolecular drugs.

引用

页码：420 / 427

页数：8

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