Reflectance Confocal Microscopy for Noninvasive Monitoring of Therapy and Detection of Subclinical Actinic Keratoses

被引：121

作者：

Ulrich, M. ^{[1
]}

Krueger-Corcoran, D. ^{[1
]}

Roewert-Huber, J. ^{[1
]}

Sterry, W. ^{[1
]}

Stockfleth, E. ^{[1
]}

Astner, S. ^{[1
]}

机构：

[1] Charite, Dept Dermatol, Skin Canc Ctr Charite, DE-10117 Berlin, Germany

来源：

DERMATOLOGY | 2010年 / 220卷 / 01期

关键词：

Actinic keratoses; Noninvasive diagnosis; Imiquimod; Monitoring; Confocal microscopy; 5-PERCENT IMIQUIMOD CREAM; SCANNING LASER MICROSCOPY; IN-VIVO; DIAGNOSTIC-ACCURACY; TOPICAL IMIQUIMOD; SOLAR KERATOSIS; DOUBLE-BLIND; MODE; MATURATION; INDUCTION;

D O I：

10.1159/000254893

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Actinic keratoses (AK) represent cutaneous carcinoma in situ and have previously been evaluated by reflectance confocal microscopy (RCM). Treatment of AK with imiquimod (IMIQ) 5% cream has been shown to 'highlight' subclinical lesions. Objective: The aim of this study was to test the applicability of RCM for noninvasive monitoring of actinic field cancerization and detection of subclinical AK. Subjects and Methods: AK and surrounding skin sites with no apparent AK of 11 volunteers were selected for imaging and subsequently classified as 'clinical' and 'subclinical' AK. IMIQ was used 3 times weekly for 4 weeks. Results: RCM was able to detect morphologic features of AK in both clinical and subclinical AK; features were more pronounced in clinical lesions. The immunomodulatory response induced by IMIQ was visualized by RCM. Conclusion: Our findings indicate that RCM allows noninvasive monitoring of treatment response in vivo and permits early detection of subclinical AK, thus substantiating the incentive for therapy. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：15 / 24

页数：10

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