FOCAL ADHESIONS: NEW ANGLES ON AN OLD STRUCTURE

被引：67

作者：

Dubash, Adi D. ^{[1
,2
]}

Menold, Marisa M. ^{[1
,2
]}

Samson, Thomas ^{[1
,2
]}

Boulter, Etienne ^{[1
,2
]}

Garcia-Mata, Rafael ^{[1
,2
]}

Doughman, Renee ^{[1
,2
]}

Burridge, Keith ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 277 | 2009年 / 277卷

关键词：

Focal adhesion; Extracellular matrix; Integrins; Syndecan-4; GEF; Rho GTPase; RhoA; Biomaterial surfaces; Mechanotransduction; Focal adhesion disassembly; PROTEIN-KINASE-C; CELL-MATRIX ADHESIONS; SMOOTH-MUSCLE-CELLS; NUCLEOTIDE EXCHANGE FACTOR; ACTIN STRESS FIBERS; SELF-ASSEMBLED MONOLAYERS; INTEGRIN-LINKED KINASE; GTP-BINDING PROTEIN; AORTIC ENDOTHELIAL-CELLS; INTERFERENCE REFLECTION MICROSCOPY;

D O I：

10.1016/S1937-6448(09)77001-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Focal adhesions have been intensely studied ever since their discovery in 1971. The last three decades have seen major advances in understanding the structure of focal adhesions and the functions they serve in cellular adhesion, migration, and other biological processes. In this chapter, we begin with a historical perspective of focal adhesions, provide an overview of focal adhesion biology, and highlight recent major advances in the field. Specifically, we review the different types of matrix adhesions and the role different Rho GTPases play in their formation. We discuss the relative contributions of integrin and syndecan adhesion receptors to the formation of focal adhesions. We also focus on new insights gained from studying focal adhesions on biomaterial surfaces and from the growing field of mechanotransduction. Throughout this chapter, we have highlighted areas of focal adhesion biology where major questions still remain to be answered.

引用

页码：1 / 65

页数：65

共 353 条

[1] LOCOMOTION OF FIBROBLASTS IN CULTURE .4. ELECTRON MICROSCOPY OF LEADING LAMELLA [J].