Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates

被引：75

作者：

Saijo, Masayuki ^{[1
]}

Ami, Yasushi ^{[2
]}

Suzaki, Yuriko ^{[2
]}

Nagata, Noriyo ^{[3
]}

Iwata, Naoko ^{[3
]}

Hasegawa, Hideki ^{[3
]}

Iizuka, Itoe ^{[1
]}

Shiota, Tomoyuki ^{[1
]}

Sakai, Kouji ^{[2
]}

Ogata, Momoko ^{[1
]}

Fukushi, Shuetsu ^{[1
]}

Mizutani, Tetsuya ^{[1
]}

Sata, Tetsutaro ^{[3
]}

Kurata, Takeshi ^{[3
]}

Kurane, Ichiro ^{[1
]}

Morikawa, Shigeru ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 1, Special Pathogens Lab, Tokyo 2080011, Japan

[2] Anim Expt Lab, Tokyo 2080011, Japan

[3] Natl Inst Infect Dis, Dept Pathol, Lab Infect Dis Pathol, Tokyo 2080011, Japan

来源：

JOURNAL OF GENERAL VIROLOGY | 2009年 / 90卷

关键词：

CYNOMOLGUS MONKEYS; EXPERIMENTAL-INFECTION; TRANSMISSION; REEMERGENCE; PATHOLOGY; SQUIRRELS; ZOONOSIS; VACCINE; DISEASE; LC16M8;

D O I：

10.1099/vir.0.010207-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Monkeypox virus is divided into Congo Basin and West African strains. The virulence and pathophysiology of two strains, Zr-599 (a Congo Basin monkeypox virus) and Liberia (a West African monkeypox virus), were evaluated in non-human primates. Four monkeys were infected by the subcutaneous (SC) and two by the intranasal (IN) inoculation routes for Zr-599 and Liberia at a dose of 10(6) p.f.u. One monkey in the Liberia/SC group was demonstrated to be co-infected with Gram-positive cocci and was excluded from analyses. Infections in three of the four Zr-599/SC monkeys and in one of the three Liberia/SC monkeys were fatal. Virus genome levels in blood in the Zr-599/SC monkeys were approximately 10 times higher than those in the Liberia/SC monkeys. Zr-599 affected respiratory, genito-urinary and gastrointestinal tract organs more severely than Liberia. Zr-599 was more virulent than Liberia and one of the factors might be the difference in organ tropism.

引用

页码：2266 / 2271

页数：6

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