Tumor-Targeting Peptide for Redox-Responsive Pt Prodrug and Gene Codelivery and Synergistic Cancer Chemotherapy

被引：6
作者：
Bai, Yaxuan [1 ]
Li, Zeyu [1 ]
Liu, Liping [2 ]
Sun, Tiedong [1 ]
Fan, Xiaocheng [1 ]
Wang, Ting [1 ]
Gou, Zhenzhen [1 ]
Tan, Shengnan [3 ]
机构：
[1] Northeast Forestry Univ, Coll Sci, Dept Chem, 26 Hexing Rd, Harbin 150040, Peoples R China
[2] Harbin First Specialist Hosp, 217 Hongwei Rd, Harbin 150056, Peoples R China
[3] Northeast Forestry Univ, Testing & Amp Anal Ctr, 26 Hexing Rd, Harbin 150040, Peoples R China
来源：
ACS APPLIED BIO MATERIALS | 2019年 / 2卷 / 04期
关键词：
gene delivery; tumor-targeting peptide; Pt prodrug; multidrug resistance;
D O I：
10.1021/acsabm.9b00065
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A new codelivery system combining prodrug strategy, siRNA/BAplatin @CRGDK NPs, to overcome cisplatin (CDDP) resistance in human breast cancer was designed and researched. Negatively charged siRNA was deposited onto the surface of tumor-targeting peptide-functionalized BAplatin@ CRGDK NPs. SiRNA/BAplatin@CRGDK NPs could facilitate cellular uptake of BAplatin and increase the cell proliferation suppression effect of Pt against MDA-MB-231/DDP cells. The tumor-to-kidney uptake ratio of the siRNA/BAplatin@ CRGDK NPs in MB-231/DDP tumors is 2.4-fold higher than that of cisplatin in MB-231/DDP tumors, thus giving rise to more significant antitumor efficacy. It demonstrated that the siRNA/BAplatin@CRGDK NPs is a potential, safe, and efficient therapeutic agent for cancer therapy.
引用
收藏
页码：1420 / 1426
页数：7
相关论文
共 27 条
[1]   Platinum group antitumor chemistry: Design and development of new anticancer drugs complementary to cisplatin [J].
Abu-Surrah, AS ;
Kettunen, M .
CURRENT MEDICINAL CHEMISTRY, 2006, 13 (11) :1337-1357
[2]   The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells [J].
Cheng, Qinqin ;
Shi, Hongdong ;
Wang, Hongxia ;
Min, Yuanzeng ;
Wang, Jun ;
Liu, Yangzhong .
CHEMICAL COMMUNICATIONS, 2014, 50 (56) :7427-7430
[3]   Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer [J].
Cong, Yuwei ;
Xiao, Haihua ;
Xiong, Hejian ;
Wang, Zigui ;
Ding, Jianxun ;
Li, Chan ;
Chen, Xuesi ;
Liang, Xing-Jie ;
Zhou, Dongfang ;
Huang, Yubin .
ADVANCED MATERIALS, 2018, 30 (11)
[4]   Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs [J].
Dai, Lin ;
Cao, Xin ;
Liu, Ke-Feng ;
Li, Chun-Xiao ;
Zhang, Gui-Feng ;
Deng, Li-Hong ;
Si, Chuan-Ling ;
He, Jing ;
Lei, Jian-Du .
JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (18) :3754-3766
[5]   γ-PGA-Coated Mesoporous Silica Nanoparticles with Covalently Attached Prodrugs for Enhanced Cellular Uptake and Intracellular GSH-Responsive Release [J].
Du, Xin ;
Xiong, Lin ;
Dai, Sheng ;
Qiao, Shi Zhang .
ADVANCED HEALTHCARE MATERIALS, 2015, 4 (05) :771-781
[6]   Intracellular Microenvironment-Responsive Dendrimer-Like Mesoporous Nanohybrids for Traceable, Effective, and Safe Gene Delivery [J].
Du, Xin ;
Xiong, Lin ;
Dai, Sheng ;
Kleitz, Freddy ;
Qiao, Shi Zhang .
ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (48) :7627-7637
[7]   Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery [J].
Du, Xin ;
Shi, Bingyang ;
Tang, Youhong ;
Dai, Sheng ;
Qiao, Shi Zhang .
BIOMATERIALS, 2014, 35 (21) :5580-5590
[8]   Developing Functionalized Dendrimer-Like Silica Nanoparticles with Hierarchical Pores as Advanced Delivery Nanocarriers [J].
Du, Xin ;
Shi, Bingyang ;
Liang, Ji ;
Bi, Jingxu ;
Dai, Sheng ;
Qiao, Shi Zhang .
ADVANCED MATERIALS, 2013, 25 (41) :5981-5985
[9]   Update of the preclinical situation of anticancer platinum complexes: Novel design strategies and innovative analytical approaches [J].
Galanski, M ;
Jakupec, MA ;
Keppler, BK .
CURRENT MEDICINAL CHEMISTRY, 2005, 12 (18) :2075-2094
[10]   Stem-Cell-Membrane Camouflaging on Near-Infrared Photoactivated Upconversion Nanoarchitectures for in Vivo Remote-Controlled Photodynamic Therapy [J].
Gao, Changyong ;
Lin, Zhihua ;
Wu, Zhiguang ;
Lin, Xiankun ;
He, Qiang .
ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (50) :34252-34260
123