Tumor-Targeting Peptide for Redox-Responsive Pt Prodrug and Gene Codelivery and Synergistic Cancer Chemotherapy

被引：6
|
作者：
Bai, Yaxuan [1 ]
Li, Zeyu [1 ]
Liu, Liping [2 ]
Sun, Tiedong [1 ]
Fan, Xiaocheng [1 ]
Wang, Ting [1 ]
Gou, Zhenzhen [1 ]
Tan, Shengnan [3 ]
机构：
[1] Northeast Forestry Univ, Coll Sci, Dept Chem, 26 Hexing Rd, Harbin 150040, Peoples R China
[2] Harbin First Specialist Hosp, 217 Hongwei Rd, Harbin 150056, Peoples R China
[3] Northeast Forestry Univ, Testing & Amp Anal Ctr, 26 Hexing Rd, Harbin 150040, Peoples R China
来源：
ACS APPLIED BIO MATERIALS | 2019年 / 2卷 / 04期
关键词：
gene delivery; tumor-targeting peptide; Pt prodrug; multidrug resistance;
D O I：
10.1021/acsabm.9b00065
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A new codelivery system combining prodrug strategy, siRNA/BAplatin @CRGDK NPs, to overcome cisplatin (CDDP) resistance in human breast cancer was designed and researched. Negatively charged siRNA was deposited onto the surface of tumor-targeting peptide-functionalized BAplatin@ CRGDK NPs. SiRNA/BAplatin@CRGDK NPs could facilitate cellular uptake of BAplatin and increase the cell proliferation suppression effect of Pt against MDA-MB-231/DDP cells. The tumor-to-kidney uptake ratio of the siRNA/BAplatin@ CRGDK NPs in MB-231/DDP tumors is 2.4-fold higher than that of cisplatin in MB-231/DDP tumors, thus giving rise to more significant antitumor efficacy. It demonstrated that the siRNA/BAplatin@CRGDK NPs is a potential, safe, and efficient therapeutic agent for cancer therapy.
引用
收藏
页码：1420 / 1426
页数：7
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