Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma

被引：29
作者：
de Araujo, Vera Cavalcanti
Altemani, Albina
Furuse, Cristiane
Martins, Marilia Trierveiler
de Araujo, Ney Soares
机构：
[1] Sao Leopoldo Mand Dent Res Inst, Dept Oral Pathol, BR-13041445 Campinas, SP, Brazil
[2] Univ Estadual Campinas, Sch Med, Dept Pathol, BR-13084917 Campinas, SP, Brazil
[3] Univ Sao Paulo, Dept Oral Pathol, Sch Dent, BR-05508000 Sao Paulo, Brazil
来源：
ORAL ONCOLOGY | 2006年 / 42卷 / 10期
基金：
巴西圣保罗研究基金会;
关键词：
myoepithelial cell; carcinoma ex-pleomorphic adenoma; myoepithelial cell markers; laminin; maspin;
D O I：
10.1016/j.oraloncology.2005.12.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The myoepithelial cell (MC) is a component of various secretory glands, including salivary glands. Besides its function, a tumor suppressor and a tumor facilitating functions have been attributed to this cell. We investigated the immunoprofile of benign MC in intraductal areas of carcinoma ex-pleomorphic adenoma (CXPA), comparing them with the MC in duct-like areas of pleomorphic adenoma, origin of the malignant tumor. Antibodies against myoepithelial markers-CK14, alpha-SMA, calponin, P63, CD10, and D2-40-plus laminin and maspin was applied in four selected cases of intracapsular and minimal invasive CXPA with only luminal. differentiation presenting areas of intraductal. carcinoma. The immunohistochemical reactions of all the antibodies showed stronger staining in benign MC surrounding the malignant epithelial. cells than in benign MC in duct-like areas of pleomorphic adenoma, thus revealing that in the malignization process the benign MC become differentiated and produce important proteins related to the tumor suppressor function. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1011 / 1016
页数：6
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