Analytical methodologies for metallomics studies of antitumor Pt-containing drugs

被引:98
作者
Esteban-Fernandez, Diego [2 ]
Moreno-Gordaliza, Estefania [1 ]
Canas, Benito [1 ]
Antonia Palacios, Maria [1 ]
Milagros Gomez-Gomez, Maria [1 ]
机构
[1] Univ Complutense Madrid, Dept Analyt Chem, E-28040 Madrid, Spain
[2] Humboldt Univ, Dept Chem, D-12489 Berlin, Germany
关键词
PLASMA-MASS SPECTROMETRY; ANTICANCER PLATINUM DRUGS; PERFORMANCE LIQUID-CHROMATOGRAPHY; METALLODRUG-PROTEIN INTERACTIONS; CISPLATIN BINDING-SITES; INTRASTRAND CROSS-LINKS; COPPER TRANSPORTER CTR1; IN-VITRO CYTOTOXICITY; INDUCED HEARING-LOSS; HUMAN SERUM-ALBUMIN;
D O I
10.1039/b911438f
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pt-containing drugs are nowadays essential components in cancer chemotherapy. However, drug resistance and side effects limit the efficiency of the treatments. In order to improve the response to Pt-based drugs, different administration strategies or new Pt-compounds have been developed with little success. The reason for this failure could be that the mechanism of action of these drugs is not completely understood. In this way, metallomics studies may contribute to clarify the interactions of Pt-containing drugs within the organism. This review is mainly focused on the role of Analytical Chemistry on the study of the interactions between Pt-based drugs and biomolecules. A summary of the analytical techniques and the most common sample treatment procedures currently used in metallomics studies of these drugs is presented. Both are of paramount importance to study these complex samples preserving the drug-biomolecule interaction. Separation and detection techniques must be carefully selected in order to achieve the intended goals. The use of multidimensional hyphenated techniques is usually necessary for a better understanding of the Pt-based drugs interactions in the organism. An overview of Pt-drugs biological interactions is presented, considering the different sample matrices and the drugs course through the organism. Samples analysed in the included studies are blood, urine, cell cytosol, DNA as well as the drugs themselves and their derivatives. However, most of these works are based on in vitro experiments or incubations of standards, leading in some cases to contradictory results depending on the experimental conditions used. Though in vivo experiments represent a great challenge due to the high complexity and the low concentrations of the Pt-adducts in real samples, these studies must be undertaken to get a deeper understanding of the real interactions concerning Pt-containing drugs.
引用
收藏
页码:19 / 38
页数:20
相关论文
共 178 条
[1]   Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 39 randomized trials [J].
Aabo, K ;
Adams, M ;
Adnitt, P ;
Alberts, DS ;
Athanazziou, A ;
Barley, V ;
Bell, DR ;
Bianchi, U ;
Bolis, G ;
Brady, MF ;
Brodovsky, HS ;
Bruckner, H ;
Buyse, M ;
Canetta, R ;
Chylak, V ;
Cohen, CJ ;
Colombo, N ;
Conte, PF ;
Crowther, D ;
Edmonson, JH ;
Gennatas, C ;
Gilbey, E ;
Gore, M ;
Guthrie, D ;
Kaye, SB ;
Laing, AH ;
Landoni, F ;
Leonard, RC ;
Lewis, C ;
Liu, PY ;
Mangioni, C ;
Marsoni, S ;
Meerpohl, H ;
Omura, GA ;
Parmar, MKB ;
Pater, J ;
Pecorelli, S ;
Presti, M ;
Sauerbrei, W ;
Skarlos, DV ;
Smalley, RV ;
Solomon, HJ ;
Stewart, LA ;
Sturgeon, JFG ;
Tattersall, MHN ;
Wharton, JT ;
Huinink, WWT ;
Tomirotti, M ;
Torri, W ;
Trope, C .
BRITISH JOURNAL OF CANCER, 1998, 78 (11) :1479-1487
[2]   Organometallic compounds in oncology: implications of novel organotins as antitumor agents [J].
Alama, Angela ;
Tasso, Bruno ;
Novelli, Federica ;
Sparatore, Fabio .
DRUG DISCOVERY TODAY, 2009, 14 (9-10) :500-508
[3]  
Allain P, 2000, DRUG METAB DISPOS, V28, P1379
[4]   Determination of drug binding sites to proteins by electrospray ionisation mass spectrometry: the interaction of cisplatin with transferrin [J].
Allardyce, CS ;
Dyson, PJ ;
Coffey, J ;
Johnson, N .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2002, 16 (10) :933-935
[5]   Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems [J].
Allardyce, CS ;
Dyson, PJ ;
Abou-Shakra, FR ;
Birtwistle, H ;
Coffey, J .
CHEMICAL COMMUNICATIONS, 2001, (24) :2708-2709
[6]  
Allen J., 1998, Proceedings of the American Association for Cancer Research Annual Meeting, V39, P159
[7]   Pharmacokinetics of cisplatin and its monohydrated complex in humans [J].
Andersson, A ;
Fagerberg, J ;
Lewensohn, R ;
Ehrsson, H .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (08) :824-827
[8]   DETERMINATION OF CISPLATIN AND CIS-DIAMINEAQUA-CHLOROPLATINUM(II) ION BY LIQUID-CHROMATOGRAPHY USING POSTCOLUMN DERIVATIZATION WITH DIETHYLDITHIOCARBAMATE [J].
ANDERSSON, A ;
EHRSSON, H .
JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 652 (02) :203-210
[9]   STABILITY OF CISPLATIN AND ITS MONOHYDRATED COMPLEX IN BLOOD, PLASMA AND ULTRAFILTRATE - IMPLICATIONS FOR QUANTITATIVE-ANALYSIS [J].
ANDERSSON, A ;
EHRSSON, H .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (4-5) :639-644
[10]   REACTIONS OF PLATINUM(II) AQUA COMPLEXES .1. MULTINUCLEAR (PT-195,N-15, AND P-13) NMR-STUDY OF REACTIONS BETWEEN THE CIS-DIAMMINEDIAQUAPLATINUM(II) CATION AND THE OXYGEN-DONOR LIGANDS HYDROXIDE, PERCHLORATE, NITRATE, SULFATE, PHOSPHATE, AND ACETATE [J].
APPLETON, TG ;
BERRY, RD ;
DAVIS, CA ;
HALL, JR ;
KIMLIN, HA .
INORGANIC CHEMISTRY, 1984, 23 (22) :3514-3521