Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

被引：13
|
作者：
Beddows, Cait A. [1 ]
Dodd, Garron T. [1 ]
机构：
[1] Univ Melbourne, Dept Anat & Physiol, Fac Med Dent & Hlth Sci, Melbourne, Vic 3010, Australia
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2021年 / 33卷 / 04期
基金：
英国医学研究理事会;
关键词：
CENTRAL-NERVOUS-SYSTEM; BROWN ADIPOSE-TISSUE; TYROSINE-PHOSPHATASE; 1B; ACTIVATED PROTEIN-KINASE; DIET-INDUCED OBESITY; ENHANCED LEPTIN SENSITIVITY; RECEPTOR IN-VIVO; FOOD-INTAKE; POMC NEURONS; HYPOTHALAMIC INSULIN;
D O I：
10.1111/jne.12947
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin signals to the brain where it coordinates multiple physiological processes underlying energy and glucose homeostasis. This review explores where and how insulin interacts within the brain parenchyma, how brain insulin signalling functions to coordinate energy and glucose homeostasis and how this contributes to the pathogenesis of metabolic disease.
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页数：20
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