Features of intrathecal immunoglobulins in patients with multiple sclerosis

被引：17

作者：

Di Pauli, Franziska ^{[1
]}

Gredler, Viktoria ^{[1
]}

Kuenz, Bettina ^{[1
]}

Lutterotti, Andreas ^{[1
]}

Ehling, Rainer ^{[1
]}

Gneiss, Claudia ^{[1
]}

Schocke, Michael ^{[2
]}

Deisenhammer, Florian ^{[1
]}

Reindl, Markus ^{[1
]}

Berger, Thomas ^{[1
]}

机构：

[1] Innsbruck Med Univ, Clin Dept Neurol, A-6020 Innsbruck, Austria

[2] Innsbruck Med Univ, Dept Radiol, A-6020 Innsbruck, Austria

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2010年 / 288卷 / 1-2期

关键词：

Multiple sclerosis; Immunoglobulins; Subclasses; Cerebrospinal fluid; Progression; Oligoclonal bands; Disease course; B cells; CEREBROSPINAL-FLUID PARAMETERS; DIAGNOSTIC-CRITERIA; OLIGOCLONAL BANDS; IGG SUBCLASSES; FC; ANTIBODIES; RECEPTORS; CORRELATE; CELLS; MRI;

D O I：

10.1016/j.jns.2009.09.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have analyzed immunoglobulin (Ig) isotypes and IgG subclasses in cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and other neurological diseases to determine whether different Ig isotype patterns correlate with clinical or paraclinical findings and CSF B cell populations. Intrathecal IgG1 synthesis was elevated in MS patients. An increased intrathecal IgM production was found in patients with a higher cerebral MRI lesion burden, whereas other clinical and paraclinical parameters were not associated with a specific Ig isotype or subclass profile. Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：147 / 150

页数：4

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