Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice

被引：29

作者：

Straub, Carolin J. ^{[1
,2
]}

Carlezon, William A., Jr. ^{[3
,4
]}

Rudolph, Uwe ^{[1
,2
]}

机构：

[1] McLean Hosp, Lab Genet Neuropharmacol, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Belmont, MA 02478 USA

[3] McLean Hosp, Behav Genet Lab, Belmont, MA 02478 USA

[4] Harvard Univ, Sch Med, Dept Psychiat, Belmont, MA 02478 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2010年 / 206卷 / 01期

关键词：

Intracranial self-stimulation; Brain stimulation reward; Diazepam; Cocaine; Mouse; C57BL/6J; INTRACRANIAL SELF-STIMULATION; CONDITIONED PLACE-PREFERENCE; SWISS-WEBSTER MICE; NUCLEUS-ACCUMBENS; ABUSE LIABILITY; MOUSE STRAINS; DOPAMINE; DRUGS; BEHAVIOR; ANXIETY;

D O I：

10.1016/j.bbr.2009.08.025

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The curve-shift variant of the intracranial self-stimulation paradigm (ICSS) is particularly useful to study drug effects on motivated behavior while distinguishing them from effects on the capability to perform the task. In this study we examined the effects of cocaine and diazepam on reward-facilitation and response rate in C57BL/6J mice, the most frequently used mouse line to study genetic modifications. Both cocaine and diazepam potentiated the rewarding effects of lateral hypothalamic brain stimulation in a dose-dependent manner and increased the rate of responding. Interestingly, the maximum decrease in ICSS thresholds was comparable for both drugs, suggesting a similar ability to affect reward and motivation despite different effects on brain reward systems. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：17 / 20

页数：4

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