Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

被引：22

作者：

Sun, Yingxiao ^{[1
]}

Liu, Xingdan ^{[2
]}

Tan, Ji ^{[2
]}

Lv, Dan ^{[1
]}

Song, Wengang ^{[3
]}

Su, Rui ^{[1
]}

Li, Ling ^{[1
]}

Liu, Xuanyong ^{[2
]}

Ouyang, Liping ^{[1
]}

Liao, Yun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Tongren Hosp, Dept Pharm, Sch Med, 1111 Xianxia Rd, Shanghai 200336, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[3] Beihua Univ, Grad Sch, Fengman Dist 132013, Jilin, Peoples R China

来源：

REGENERATIVE BIOMATERIALS | 2021年 / 8卷 / 01期

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

Polyetheretherketone; sulfonation; strontium ranelate; osseointegration; KAPPA-B LIGAND; NUCLEAR-FACTOR; BONE LOSS; IN-VITRO; OSTEOPOROSIS; WOMEN; BIOACTIVITY; OSTEOBLAST; ACTIVATOR; COLLAGEN;

D O I：

10.1093/rb/rbaa043

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Polyetheretherketone (PEEK) has been used as an implant material because it has similar mechanical properties to natural bone. However, inferior osseointegration and bioinertness hamper the clinical application of PEEK. In this study, the surfaces of sulfonated three-dimensional (3D) PEEK porous structures were loaded with different concentrations of strontium ranelate, a compound commonly used in the treatment or prevention of osteoporosis by promoting bone formation and inhibiting bone resorption. Field-emission scanning electron microscopy was used to characterize the topography of the structures, elemental carbon, oxygen and strontium contents were measured by X-ray photoelectron spectroscopy, and surface zeta potentials and water-contact angle were also measured. The results indicated that strontium ranelate was successfully loaded onto the 3D porous structures. In vitro cellular results showed that strontium ranelate-treated sulfonated PEEK (SP-SR) strengthened the adhesion of MC3T3-E1 cells. The activity of alkaline phosphatase, collagen secretion and extracellular matrix mineralization deposition of MC3T3-E1 cells were also improved on the surface of SP-SR. These results indicate that SP-SR could serve a new implant candidate for surgical treatment.

引用

页数：9

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