A comprehensive guide to the ROMK potassium channel: form and function in health and disease

被引：139

作者：

Welling, Paul A. ^{[1
]}

Ho, Kevin ^{[2
]}

机构：

[1] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

[2] Univ Pittsburgh, Dept Med, Renal Electrolyte Div, Pittsburgh, PA USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2009年 / 297卷 / 04期

关键词：

K(ir)1.1; KCNJ; inward-rectifying potassium channel; Bartter's syndrome; pseudohypoaldosteronism type II; serine- and glucocorticoid-regulated kinase-1; WNK kinase; phosphatidylinositol 4,5-bisphosphate; CORTICAL-COLLECTING DUCT; CONDUCTANCE K+ CHANNEL; THICK ASCENDING LIMB; PROTEIN-KINASE-A; CALCIUM-SENSING RECEPTOR; BARTTERS-SYNDROME; APICAL MEMBRANE; INWARD RECTIFICATION; SURFACE EXPRESSION; SELECTIVITY FILTER;

D O I：

10.1152/ajprenal.00181.2009

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Welling PA, Ho K. A comprehensive guide to the ROMK potassium channel: form and function in health and disease. Am J Physiol Renal Physiol 297: F849-F863, 2009. First published May 20, 2009; doi:10.1152/ajprenal.00181.2009.-The discovery of the renal outer medullary K+ channel (ROMK, K(ir)1.1), the founding member of the inward-rectifying K+ channel (K-ir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

引用

页码：F849 / F863

页数：15

共 176 条

[1] PKA-induced stimulation of ROMK1 channel activity is governed by both tethering and non-tethering domains of an A Kinase Anchor Protein [J].

Ali, S ;

Wei, Y ;

Lerea, KM ;

Becker, L ;

Rubin, CS ;

Wang, WH .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2001, 11 (03) :135-142

[2] The A kinase anchoring protein is required for mediating the effect of protein kinase A on ROMK1 channels [J].

Ali, S ;

Chen, X ;

Lu, M ;

Xu, JZ ;

Lerea, KM ;

Hebert, SC ;

Wang, WH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10274-10278

[3] A view of SUR/KIR6.X, KATP channels [J].

Babenko, AP ;

Aguilar-Bryan, L ;

Bryan, J .

ANNUAL REVIEW OF PHYSIOLOGY, 1998, 60 :667-687

[4] Maxi-K channels contribute to urinary potassium excretion in the ROMK- deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet [J].

Bailey, M. A. ;

Cantone, A. ;

Yan, Q. ;

MacGregor, G. G. ;

Leng, Q. ;

Amorim, J. B. O. ;

Wang, T. ;

Hebert, S. C. ;

Giebisch, G. ;

Malnic, G. .

KIDNEY INTERNATIONAL, 2006, 70 (01) :51-59

[5] HYPERPLASIA OF JUXTAGLOMERULAR COMPLEX WITH HYPERALDOSTERONISM AND HYPOKALEMIC ALKALOSIS - A NEW SYNDROME [J].

BARTTER, FC ;

PRONOVE, P ;

GILL, JR ;

MACCARDLE, RC .

AMERICAN JOURNAL OF MEDICINE, 1962, 33 (06) :811-&

[6] A gate in the selectivity filter of potassium channels [J].

Bernèche, S ;

Roux, BI .

STRUCTURE, 2005, 13 (04) :591-600

[7] Energetics of ion conduction through the K+ channel [J].

Bernèche, S ;

Roux, B .

NATURE, 2001, 414 (6859) :73-77

[8] Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure [J].

Birkenhäger, R ;

Otto, E ;

Schürmann, MJ ;

Vollmer, M ;

Ruf, EM ;

Maier-Lutz, I ;

Beekmann, F ;

Fekete, A ;

Omran, H ;

Feldmann, D ;

Milford, DV ;

Jeck, N ;

Konrad, M ;

Landau, D ;

Knoers, NVAM ;

Antignac, C ;

Sudbrak, R ;

Kispert, A ;

Hildebrandt, F .

NATURE GENETICS, 2001, 29 (03) :310-314

[9] ROMK INWARDLY RECTIFYING ATP-SENSITIVE K+ CHANNEL .2. CLONING AND DISTRIBUTION OF ALTERNATIVE FORMS [J].

BOIM, MA ;

HO, K ;

SHUCK, ME ;

BIENKOWSKI, MJ ;

BLOCK, JH ;

SLIGHTOM, JL ;

YANG, YH ;

BRENNER, BM ;

HEBERT, SC .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1995, 268 (06) :F1132-F1140

[10] VASOPRESSIN INCREASES DENSITY OF APICAL LOW-CONDUCTANCE K+ CHANNELS IN RAT CCD [J].

CASSOLA, AC ;

GIEBISCH, G ;

WANG, WH .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (03) :F502-F509

← 1 2 3 4 5 6 7 8 9 10 →