Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells

被引：87

作者：

Perez-Persona, Ernesto ^{[1
]}

Mateo, Gema ^{[1
]}

Garcia-Sanz, Ramon ^{[1
,2
]}

Mateos, Maria-Victoria ^{[1
]}

de las Heras, Natalia ^{[3
]}

Garcia de Coca, Alfonso ^{[4
]}

Hernandez, Jose M. ^{[5
]}

Galende, Josefina ^{[6
]}

Martin-Nunez, Guillermo ^{[7
]}

Barez, Abelardo ^{[8
]}

Alonso, Jose M. ^{[9
]}

Martin, Alejandro ^{[10
]}

Lopez-Berges, Consuelo ^{[1
]}

Orfao, Alberto ^{[2
,11
]}

San Miguel, Jesus F. ^{[1
,2
]}

Vidriales, Maria-Belen ^{[1
,2
]}

机构：

[1] Hosp Univ Salamanca, Dept Haematol, Salamanca 37007, Spain

[2] Univ Salamanca, CSIC, Ctr Invest Canc, E-37008 Salamanca, Spain

[3] Complejo Hosp, Dept Haematol, Leon, Spain

[4] Univ Hosp, Dept Haematol, Valladolid, Spain

[5] Gen Hosp, Dept Haematol, Segovia, Spain

[6] Hosp Comarcal del Bierzo, Dept Haematol, Leon, Spain

[7] Hosp Nuestra Senora del Puerto de Plasencia, Dept Haematol, Caceres, Spain

[8] Hosp Nuestra Senora de Sonsoles, Dept Haematol, Palencia, Spain

[9] Hosp Rio Carrion, Dept Haematol, Palencia, Spain

[10] Hosp Virgen de la Concha, Dept Haematol, Zamora, Spain

[11] Univ Salamanca, Dept Cytometry, E-37008 Salamanca, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 148卷 / 01期

关键词：

smouldering myeloma; MGUS; evolving pattern; flow cytometry; risk of progression; MULTIPLE-MYELOMA; UNDETERMINED SIGNIFICANCE;

D O I：

10.1111/j.1365-2141.2009.07929.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>The present study explored the impact of two novel criteria; having > 95% abnormal plasma cells by flow cytometry at diagnosis and the evolving subtype of the disease, as predictors of progression in 61 smouldering multiple myeloma (SMM) and 311 monoclonal gammopathy of unknown significance (MGUS) patients. Although both criteria were of prognostic value, the risk of progression was better identified by immunophenotyping [Hazard Ratio (HR) 6 center dot 2 and 17 center dot 2 for SMM and MGUS, respectively] than evolving subtype, which had independent prognostic value only in MGUS (HR 3 center dot 6). Immunophenotyping discriminated the different risk of progression within the evolving and non-evolving subgroups of SMM (P = 0 center dot 01) and MGUS (P < 0 center dot 001).

引用

页码：110 / 114

页数：5

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