Smart materials: in situ gel-forming systems for nasal delivery

被引：130
作者：
Karavasili, Christina [1 ]
Fatouros, Dimitrios G. [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Technol, Thessaloniki 54124, Greece
来源：
DRUG DISCOVERY TODAY | 2016年 / 21卷 / 01期
关键词：
DRUG-DELIVERY; INTRANASAL DELIVERY; KETOROLAC TROMETHAMINE; THERMOREVERSIBLE GEL; GELLING SYSTEMS; FORMULATION; VITRO; BIOAVAILABILITY; HYDROGELS; CHITOSAN;
D O I：
10.1016/j.drudis.2015.10.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the last decade in situ gelling systems have emerged as a novel approach in intranasal delivery of therapeutics, capturing the interest of scientific community. Considerable advances have been currently made in the development of novel formulations containing both natural and synthetic polymers. In this paper we present recent developments on in situ gelling systems for nasal delivery, highlighting the mechanisms that govern their formation.
引用
收藏
页码：157 / 166
页数：10
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