Xenofuranones A and B:: Phenylpyruvate dimers from Xenorhabdus szentirmaii

被引：60
作者：
Brachmann, Alexander O.
Forst, Steven
Furgani, Ghazala M.
Fodor, Andras
Bode, Helge B.
机构：
[1] Univ Saarland, D-66041 Saarbrucken, Germany
[2] Univ Wisconsin, Dept Biol Sci, Milwaukee, WI 53201 USA
[3] Eotvos Lorand Univ, Dept Genet, Budapest, Hungary
[4] Ohio State Univ, Dept Entomol, Wooster, OH 44691 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 12期
关键词：
D O I：
10.1021/np060409n
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Xenofuranones A (1) and B (2) have been isolated from cultures of the insect-pathogenic bacterium Xenorhabdus szentirmaii, and their structures were elucidated by NMR and mass spectroscopy. Both compounds show similarities to fungal furanones, and their biosynthesis was studied using a reversed approach by feeding putative C-12 precursors to an overall C-13 background in small-scale experiments followed by gas chromatographic analysis coupled to mass spectrometry.
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收藏
页码：1830 / 1832
页数：3
相关论文
共 18 条
[1]   Insecticidal toxins from the bacterium Photorhabdus luminescens [J].
Bowen, D ;
Rocheleau, TA ;
Blackburn, M ;
Andreev, O ;
Golubeva, E ;
Bhartia, R ;
ffrench-Constant, RH .
SCIENCE, 1998, 280 (5372) :2129-2132
[2]   Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom [J].
Brady, SF ;
Clardy, J .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (43) :7045-7048
[3]   Txp40, a ubiquitous insecticidal toxin protein from Xenorhabdus and Photorhabdus bacteria [J].
Brown, SE ;
Cao, AT ;
Dobson, P ;
Hines, ER ;
Akhurst, RJ ;
East, PD .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (02) :1653-1662
[4]   Photobactin:: a catechol siderophore produced by Photorhabdus luminescens, an entomopathogen mutually associated with Heterorhabditis bacteriophora NC1 nematodes [J].
Ciche, TA ;
Blackburn, M ;
Carney, JR ;
Ensign, JC .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (08) :4706-4713
[5]   Photorhabdus:: towards a functional genomic analysis of a symbiont and pathogen [J].
Ffrench-Constant, R ;
Waterfield, N ;
Daborn, P ;
Joyce, S ;
Bennett, H ;
Au, C ;
Dowling, A ;
Boundy, S ;
Reynolds, S ;
Clarke, D .
FEMS MICROBIOLOGY REVIEWS, 2003, 26 (05) :433-456
[6]   Xenorhabdus and Photorhabdus spp.: Bugs that kill bugs [J].
Forst, S ;
Dowds, B ;
Boemare, N ;
Stackebrandt, E .
ANNUAL REVIEW OF MICROBIOLOGY, 1997, 51 :47-72
[7]   Molecular biology of the symbiotic pathogenic bacteria Xenorhabdus spp and Photorhabdus spp [J].
Forst, S ;
Nealson, K .
MICROBIOLOGICAL REVIEWS, 1996, 60 (01) :21-&
[8]   Human infection with Photorhabdus asymbiotica:: an emerging bacterial pathogen [J].
Gerrard, J ;
Waterfield, N ;
Vohra, R ;
ffrench-Constant, R .
MICROBES AND INFECTION, 2004, 6 (02) :229-237
[9]  
KIRIYAMA N, 1977, CHEM PHARM BULL, V25, P2593
[10]   Description of four novel species of Xenorhabdus, family Enterobacteriaceae:: Xenorhabdus budapestensis sp nov., Xenorhabdus ehlersii sp nov., Xenorhabdus innexi sp nov., and Xenorhabdus szentirmaii sp nov. [J].
Lengyel, K ;
Lang, E ;
Fodor, A ;
Szállás, E ;
Schumann, P ;
Stackebrandt, E .
SYSTEMATIC AND APPLIED MICROBIOLOGY, 2005, 28 (02) :115-122
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