Diffuse optical spectroscopy of breast tissue extended to 1100 nm

被引：65

作者：

Taroni, Paola ^{[1
,2
]}

Bassi, Andrea ^{[1
,3
]}

Comelli, Daniela ^{[1
]}

Farina, Andrea ^{[1
]}

Cubeddu, Rinaldo ^{[1
,3
]}

Pifferi, Antonio ^{[1
,3
]}

机构：

[1] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy

[2] CNR, Ist Foton & Nanotecnol, I-20133 Milan, Italy

[3] CNR, Natl Lab Ultrafast & Ultraintense Opt Sci, I-20133 Milan, Italy

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2009年 / 14卷 / 05期

关键词：

absorption spectroscopy; breast; collagen; photon migration; tissue composition; tissue diagnostics; MAMMOGRAPHIC DENSITY; CANCER; REFLECTANCE; ABSORPTION; WATER;

D O I：

10.1117/1.3251051

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The feasibility of in vivo measurements in the range of 1000 to 1100 nm and the potential benefits of operation in that wavelength range for diagnostic applications are investigated. To this purpose, an existing system for time-resolved diffuse spectroscopy is modified to enable in vivo studies to be carried out continuously from 600 to 1100 nm. The optical characterization of collagen powder is extended to 1100 nm and an accurate measurement of the absorption properties of lipid is carried out over the entire spectral range. Finally, the first in vivo absorption and scattering spectra of breast tissue are measured from 10 healthy volunteers between 600 and 1100 nm and tissue composition is evaluated in terms of blood parameters and water, lipid, and collagen content using a spectrally constrained global fitting procedure. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3251051]

引用

页数：7

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