Phosphatidylcholine's functions beyond that of a membrane brick

被引：115

作者：

Furse, Samuel ^{[1
]}

de Kroon, Anton I. P. M. ^{[1
]}

机构：

[1] Univ Utrecht, Membrane Biochem & Biophys, Padualaan 8, NL-3584 CH Utrecht, Netherlands

来源：

MOLECULAR MEMBRANE BIOLOGY | 2015年 / 32卷 / 04期

关键词：

Lipid isoforms; lipid signalling; phosphatidylcholine; PHASE-TRANSITIONS; CELL-MEMBRANES; MODULATORS; DRIVEN; MODEL;

D O I：

10.3109/09687688.2015.1066894

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its discovery in the 19th century, phosphatidylcholine (PC) has been regarded primarily as a structural lipid. However, more recent evidence, much of it in the last five years, strongly suggests that PC has other roles. Here, we explore some of that new evidence and consider the possibility that the ultimate role of phosphatidylcholine may not be predictable.

引用

页码：117 / 119

页数：3

共 24 条

[1]

BILLS TK, 1975, FED PROC, V34, P790

[2] Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver [J].

Chakravarthy, Manu V. ;

Lodhi, Irfan J. ;

Yin, Li ;

Malapaka, Raghu R. V. ;

Xu, H. Eric ;

Turk, John ;

Semenkovich, Clay F. .

CELL, 2009, 138 (03) :476-488

[3] LIPID PHASE-TRANSITIONS IN MODEL BIOMEMBRANES - EFFECT OF IONS ON PHOSPHATIDYLCHOLINE BILAYERS [J].

CHAPMAN, D ;

PEEL, WE ;

KINGSTON, B ;

LILLEY, TH .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 464 (02) :260-275

[4] Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance [J].

Chibalin, Alexander V. ;

Leng, Ying ;

Vieira, Elaine ;

Krook, Anna ;

Bjoernholm, Marie ;

Long, Yun Chau ;

Kotova, Olga ;

Zhong, Zhihui ;

Sakane, Fumio ;

Steiler, Tatiana ;

Nylen, Carolina ;

Wang, Jianjun ;

Laakso, Markku ;

Topham, Matthew K. ;

Gilbert, Marc ;

Wallberg-Henriksson, Harriet ;

Zierath, Juleen R. .

CELL, 2008, 132 (03) :375-386

[5] PHOSPHOLIPID PHASE-TRANSITIONS EFFECTS OF NORMAL-ALCOHOLS, NORMAL-MONOCARBOXYLIC ACIDS, PHENYLALKYL ALCOHOLS AND QUATERNARY AMMONIUM-COMPOUNDS [J].

ELIASZ, AW ;

CHAPMAN, D ;

EWING, DF .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 448 (02) :220-230

[6] Phosphatidylcholine Transfer Protein Interacts with Thioesterase Superfamily Member 2 to Attenuate Insulin Signaling [J].

Ersoy, Baran A. ;

Tarun, Akansha ;

D'Aquino, Katharine ;

Hancer, Nancy J. ;

Ukomadu, Chinweike ;

White, Morris F. ;

Michel, Thomas ;

Manning, Brendan D. ;

Cohen, David E. .

SCIENCE SIGNALING, 2013, 6 (286) :ra64

[7]

Furse Samuel, 2015, Journal of Chemical Biology, V8, P1, DOI 10.1007/s12154-014-0117-x

[8]

Gobley T., 1874, J PHARM CHIM, V19, P346

[9] Phospholipases C and sphingomyelinases: Lipids as substrates and modulators of enzyme activity [J].

Goni, Felix M. ;

Montes, L-Ruth ;

Alonso, Alicia .

PROGRESS IN LIPID RESEARCH, 2012, 51 (03) :238-266

[10] AFFINITY OF PHOSPHATIDYLCHOLINE MOLECULAR-SPECIES FOR THE BOVINE PHOSPHATIDYLCHOLINE AND PHOSPHATIDYLINOSITOL TRANSFER PROTEINS - PROPERTIES OF THE SN-1 AND SN-2 ACYL BINDING-SITES [J].

KASURINEN, J ;

VANPARIDON, PA ;

WIRTZ, KWA ;

SOMERHARJU, P .

BIOCHEMISTRY, 1990, 29 (37) :8548-8554

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