Lodopyridone, a Structurally Unprecedented Alkaloid from a Marine Actinomycete

被引：60

作者：

Maloney, Katherine N. ^{[1
]}

MacMillan, John B. ^{[1
]}

Kauffman, Christopher A. ^{[1
]}

Jensen, Paul R. ^{[1
]}

DiPasquale, Antonio G. ^{[2
]}

Rheingold, Arnold L. ^{[2
]}

Fenical, William ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Chem & Biochem, Small Mol Crystallog Facil, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 23期

关键词：

BACTERIUM; INHIBITOR;

D O I：

10.1021/ol901997k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC50 = 3.6 mu M.

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收藏

页码：5422 / 5424

页数：3

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