Sex-Determining Region Y Chromosome-Related High-Mobility-Group Box 10 in Cancer: A Potential Therapeutic Target

被引：4
|
作者：
Yu, Liming [1 ,2 ]
Peng, Fan [3 ]
Dong, Xue [4 ]
Chen, Ying [5 ]
Sun, Dongdong [3 ]
Jiang, Shuai [3 ]
Deng, Chao [1 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiovasc Surg, Xian, Peoples R China
[2] Gen Hosp Northern Theater Command, Dept Cardiovasc Surg, Shenyang, Peoples R China
[3] Airforce Mil Med Univ, Xijing Hopspital, Dept Cardiol, Xian, Peoples R China
[4] Gen Hosp Northern Theater Command, Outpatient Dept Liaoning Mil Reg, Shenyang, Peoples R China
[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hematol, Xian, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
sex-determining region Y-related high mobility group-box 10 (SOX10); cancer; developmental biology; melanoma; breast cancer; TRANSCRIPTION FACTOR SOX10; SALIVARY-GLAND TUMORS; NEURAL CREST; MELANOCYTE DEVELOPMENT; MALIGNANT-MELANOMA; STEM-CELLS; HEPATOCELLULAR-CARCINOMA; MESENCHYMAL TRANSITION; MOLECULAR-MECHANISM; DOWN-REGULATION;
D O I：
10.3389/fcell.2020.564740
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sex-determining region Y-related high mobility group-box 10 (SOX10), a member of the SOX family, has recently been highlighted as an essential transcriptional factor involved in developmental biology. Recently, the functionality of SOX 10 has been increasingly revealed by researchers worldwide. It has been reported that SOX10 significantly regulates the proliferation, migration, and apoptosis of tumors and is closely associated with the progression of cancer. In this review, we first introduce the basic background of the SOX family and SOX10 and then discuss the pathophysiological roles of SOX10 in cancer. Besides, we enumerate the application of SOX10 in the pathological diagnosis and therapeutic potential of cancer. Eventually, we summarize the potential directions and perspectives of SOX10 in neoplastic theranostics. The information compiled herein may assist in additional studies and increase the potential of SOX10 as a therapeutic target for cancer.
引用
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页数：14
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