Copper-Catalyzed Cascade Addition/Cyclization: An Efficient and Versatile Synthesis of N-Substituted 2-Heterobenzimidazoles

被引：99

作者：

Lv, Xin ^{[1
]}

Bao, Weiliang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 15期

关键词：

COUPLING REACTIONS; C-N; REGIOSELECTIVE SYNTHESIS; NITROGEN-HETEROCYCLES; AZOLIUM AZOLATE; BENZIMIDAZOLES; DERIVATIVES; ARYL; INHIBITORS; DISCOVERY;

D O I：

10.1021/jo900743y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient one-pot synthesis of various N-substituted 2-heterobenzimidazoles has been developed. Through a Cu(I)-catalyzed cascade intermolecular addition/intramolecular C-N coupling process, a wide variety of 2-heterobenzimidazoles could be synthesized from o-haloarylcarbodiimides and N- or O-nucleophiles.

引用

页码：5618 / 5621

页数：4

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