Small molecule probes that target Abl kinase

被引：32

作者：

Kalesh, Karunakaran A. ^{[1
]}

Sim, Derek S. B. ^{[1
]}

Wang, Jigang ^{[2
]}

Liu, Kai ^{[2
]}

Lin, Qingsong ^{[2
]}

Yao, Shao Q. ^{[1
,2
,3
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

[3] Natl Univ Singapore, MedChem Program, Inst Life Sci, Singapore 117543, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 07期

关键词：

GAMMA-SECRETASE INHIBITORS; AFFINITY PROBES; TYROSINE KINASE; PROTEIN-KINASES; CROSS-LINKER; MECHANISM; METALLOPROTEASES; IDENTIFICATION;

D O I：

10.1039/b919888a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.

引用

页码：1118 / 1120

页数：3

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