The role of voltage-gated calcium channels in pain and nociception

被引：36
作者：
Gribkoff, Valentin K. [1 ]
机构：
[1] Knopp Neurosci Inc, Pittsburgh, PA 15219 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 05期
关键词：
ion channel; voltage-gated; calcium; drug discovery; modulation; pain; neuropathic pain; N-type calcium channel; T-type calcium channel; L-type calcium channel; P/Q-type calcium channel; R-type calcium channel; review;
D O I：
10.1016/j.semcdb.2006.09.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of ion channels found throughout the central nervous system (CNS) and the periphery. Neuronal functions include the control of neurotransmitter release and neuronal excitability in important pain pathways. In the current review we will give an overview of the data that has been generated in support of these channels performing a pivotal role in the pain pathway. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码：555 / 564
页数：10
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