Allelic variation of the serotonin transporter gene polymorphic region in apes

被引：13

作者：

Inoue-Murayama, M ^{[1
]}

Niimi, Y

Takenaka, O

Okada, K

Matsuzaki, I

Ito, S

Murayama, Y

机构：

[1] Gifu Univ, Fac Agr, Dept Biol Divers & Resources, Gifu 50111, Japan

[2] Kyoto Univ, Inst Primate Res, Inuyama, Aichi, Japan

[3] Univ Tsukuba, Inst Environm Sci, Ibaraki, Osaka, Japan

[4] Univ Tsukuba, Inst Community Med, Ibaraki, Osaka, Japan

[5] Natl Inst Anim Hlth, Tsukuba, Ibaraki 3058056, Japan

来源：

PRIMATES | 2000年 / 41卷 / 03期

关键词：

serotonin transporter; promoter sequence; allelic variation; hominization;

D O I：

10.1007/BF02557596

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

To assess the change of serotonin transporter (5-HTT) gene-linked polymorphic region that has occurred during the process of hominization, we examined the allelic variation of 5-HTT gene-linked polymorphic region (5-HTTLPR) in anthropoid apes such as chimpanzees, gorillas, orang-utans, and gibbons, and determined the DNA sequences of the alleles in each species. All chimpanzees examined shared only the 17.5 repeat allele, while polymorphism was observed in the other apes and the 16 and 20 repeat alleles were most frequent in gorillas and orang-utans, respectively. 5-HTTLPR was highly polymorphic in gibbons and the 17 and 23 repeat alleles were most common among 5 alleles. Alleles with extra-long repeated (22 and 23) sequences were found in orang-utans and gibbons, and the alleles of these Asian apes were similar to the rhesus monkey allele.

引用

页码：267 / 273

页数：7

共 18 条

[1] A novel allelic variant of the human serotonin transporter gene regulatory polymorphism [J].

Delbrück, SJW ;

Wendel, B ;

Grunewald, I ;

Sander, T ;

Morris-Rosendahl, D ;

Crocq, MA ;

Berrettini, WH ;

Hoehe, MR .

CYTOGENETICS AND CELL GENETICS, 1997, 79 (3-4) :214-220

[2] Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism [J].

Flory, JD ;

Manuck, SB ;

Ferrell, RE ;

Dent, KM ;

Peters, DG ;

Muldoon, MF .

MOLECULAR PSYCHIATRY, 1999, 4 (01) :93-96

[3] Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects [J].

Gelernter, J ;

Kranzler, H ;

Coccaro, EF ;

Siever, LJ ;

New, AS .

AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (10) :1332-1338

[4] A new west African chimpanzee subspecies? [J].

Gonder, MK ;

Oates, JF ;

Disotell, TR ;

Forstner, MRJ ;

Morales, JC ;

Melnick, DJ .

NATURE, 1997, 388 (6640) :337-337

[5]

Greenberg BD, 1999, AM J MED GENET, V88, P83, DOI 10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO

[6]

2-0

[7]

Heils A, 1996, J NEUROCHEM, V66, P2621

[8] An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population [J].

Ishiguro, H ;

Arinami, T ;

Yamada, K ;

Otsuka, Y ;

Toru, M ;

Shibuya, H .

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 1997, 51 (05) :333-335

[9] Association between serotonin transporter gene polymorphism and anxiety-related traits [J].

Katsuragi, S ;

Kunugi, H ;

Sano, A ;

Tsutsumi, T ;

Isogawa, K ;

Nanko, S ;

Akiyoshi, J .

BIOLOGICAL PSYCHIATRY, 1999, 45 (03) :368-370

[10] Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population [J].

Kumakiri, C ;

Kodama, K ;

Shimizu, E ;

Yamanouchi, N ;

Okada, S ;

Noda, S ;

Okamoto, H ;

Sato, T ;

Shirasawa, H .

NEUROSCIENCE LETTERS, 1999, 263 (2-3) :205-207

← 1 2 →