Serum lipoprotein (a) is associated with increased risk of stroke in Chinese adults: A prospective study

被引：17
|
作者：
Zhang, Jie [1 ,2 ]
Du, Rui [2 ]
Peng, Kui [2 ]
Wu, Xueyan [2 ]
Hu, Chunyan [2 ]
Li, Mian [2 ]
Xu, Yu [2 ]
Xu, Min [2 ]
Wang, Shuangyuan [2 ]
Bi, Yufang [2 ]
Wang, Weiqing [2 ]
Lu, Jieli [2 ]
Chen, Yuhong [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp North, Dept Endocrine & Metab Dis, 999 Xi Wang Rd, Shanghai 201801, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Natl Clin Res Ctr Metab Dis, Dept Endocrine & Metab Dis,Rui Jin Hosp,Sch Med, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China
来源：
ATHEROSCLEROSIS | 2019年 / 289卷
基金：
中国国家自然科学基金;
关键词：
Prospective cohort study; Lipoprotein (a); Stroke; INCIDENT ISCHEMIC-STROKE; LOW-DENSITY-LIPOPROTEIN; HEMORRHAGIC STROKE; ATHEROSCLEROSIS RISK; CHOLESTEROL; APOLIPOPROTEIN(A); DISEASE; MORTALITY; SUBTYPES; GENETICS;
D O I：
10.1016/j.atherosclerosis.2019.07.025
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and aims: Epidemiological evidence on the association between elevated lipoprotein (a) (Lp (a)) with risk of stroke remains inconsistent. We aimed to investigate the association between serum Lp (a) level and the risk of stroke among middle-aged and elderly Chinese. Methods: A community-based prospective cohort study of 8500 participants aged 40 years or older was conducted in Jiading district, Shanghai, China, in 2010. The incident strokes were documented at follow-up visit during 2014-2015. Results: During a mean follow-up of 5.1 years, 444 incident cases of stroke occurred. The incidences of stroke were 4.44%, 5.14% and 6.14% from the lowest to the highest serum Lp (a) tertile, respectively. A significant association between serum Lp (a) tertile and the risk of incident stroke was observed (p for trend < 0.05). Compared with individuals in the lowest tertile of serum Lp (a), the multivariable adjusted hazards ratio (HR) and 95% confidence interval (CI) for incident stroke in Lp (a) tertile 3 were 1.34 (1.06-1.70). Conclusions: Serum Lp (a) concentration was associated with increased risk of incident stroke in Chinese adults.
引用
收藏
页码：8 / 13
页数：6
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