RETRACTED: Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research (Retracted article. See vol 241, pg 98, 2007)

被引：103
作者：
Hwang, Eun-Sun
Kim, Gun-Hee
机构：
[1] Seoul Natl Univ, Coll Agr & Life Sci, Ctr Agr Biomat, Seoul 151921, South Korea
[2] Duksung Womens Univ, Dept Food & Nutr, Seoul 132714, South Korea
[3] Duksung Womens Univ, Plant Resources Res Inst, Seoul 132714, South Korea
来源：
TOXICOLOGY | 2007年 / 229卷 / 1-2期
关键词：
biomarker; oxidative stress; DNA damage; lipid peroxidation; protein damage; cancer;
D O I：
10.1016/j.tox.2006.10.013
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Oxidation and the production of free radicals are an integral part of human metabolism, and oxidative stress is related to many diseases, including cancer and heart disease. The use of biomarkers for oxidative stress may provide further evidence of a causal relationship between oxidative damage to macromolecules (DNA, lipids, and proteins) and cancer. A wide variety of functional assays, both in vivo and ex vivo, include various measures of DNA oxidation (oxidized DNA bases such as 8-OHdG, autoantibodies to oxidized DNA, modified comet assay), lipid oxidation (thiobarbituric acid-reactive substances, exhaled pentane/ethane, low-density lipoprotein resistance to oxidation, isoprostanes), and protein oxidation (protein carbonyls). The objective of this review is to discuss characteristics and methodologic issues for studies involving biomarkers of exposure to antioxidant nutrients and of oxidative stress status. This paper provides an overview on the current knowledge of oxidative DNA, lipid, and protein damage and cancer incidence. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：1 / 10
页数：10
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