First Efficient Palladium-Catalyzed Aminations of Pyrimidines, 1,2,4-Triazines and Tetrazines by Original Methyl Sulfur Release

被引：10

作者：

Pellegatti, Laurent ^{[1
]}

Vedrenne, Emeline ^{[1
]}

Leger, Jean-Michel ^{[2
]}

Jarry, Christian ^{[2
]}

Routier, Sylvain ^{[1
]}

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, UMR CNRS 6005, F-45067 Orleans 2, France

[2] Univ Bordeaux 2, EA Pharmacochim 4138, F-33076 Bordeaux, France

来源：

SYNLETT | 2009年 / 13期

关键词：

aminations; cross-coupling; palladium; copper; sulfur; DIELS-ALDER REACTIONS; ARYL;

D O I：

10.1055/s-0029-1217699

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient and original palladium-catalyzed amination of pyrimidines, 1,2,4-triazines and tetrazines is reported. Starting from triazine 1, a Buchwald-Hartwig-type reaction leads to the formation of heterocycle 2 via methyl sulfur release. This reaction was generalized to the use of a wide range of amines in good to excellent yields.

引用

页码：2137 / 2142

页数：6

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