ANTIOXIDANT ACTIVITY AND α-AMYLASE INHIBITORY EFFECT OF POLYPHENOLIC-RICH EXTRACT FROM ORIGANUM GLANDULOSUM DESF

被引：12
作者：
Bejaoui, Afef [1 ]
Boulila, Abdennacer [2 ]
Sanaa, Adnen
Boussaid, Mohamed [1 ]
Fernandez, Xavier [3 ]
机构：
[1] Natl Inst Appl Sci & Technol, Ctr Urbain Nord, Plant Biotechnol Lab, B P 676, Tunis 1080, Tunisia
[2] Natl Inst Res & Physico Chem Analyses, Lab Nat Subst LR10INRAP02, Biotechpole Sidi Thabet, Ariana 2020, Tunisia
[3] Univ Nice, CNRS, UMR 7272, Inst Chim Nice, F-06108 Nice 2, France
来源：
JOURNAL OF FOOD BIOCHEMISTRY | 2017年 / 41卷 / 01期
关键词：
ESSENTIAL OIL COMPOSITION; IN-VITRO ANTIOXIDANT; ANTIFUNGAL PROPERTIES; CHEMICAL-COMPOSITION; PHENOLIC-COMPOUNDS; MASS-SPECTROMETRY; OFFICINALIS L; SSP VULGARE; DERIVATIVES; FLAVONOIDS;
D O I：
10.1111/jfbc.12271
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The polyphenolic-rich extract of Tunisian Origanum glandulosum Desf. was investigated for its phenolic composition, antioxidant activity and potential to contribute to the dietary management of type II diabetes. By mean of an ultra-performance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-PDA-ESI-MS) 16 phenolics were characterized. The major detected compounds are caffeic acid, luteloin glucoside, xanthomicrol and carvacrol. The polyphenolic-rich extract presented a notable antioxidant activity similar to that of the synthetic antioxidant Trolox. It was found to inhibit, in a concentration dependent manner, the alpha-amylase activity with an IC50 value (8.22 mg/mL) comparable to that of Acarbose (6.12 mg/mL). Overall, our findings suggest that O. glandulosum could be considered as a valuable source of high-value phytochemicals with pharmaceutical and functional food additive applications.
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页数：8
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