Enantioselective synthesis of decarestrictine J

被引：13
作者：
Chowdhury, Partha Sarathi [1 ]
Gupta, Priti [1 ]
Kumar, Pradeep [1 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 51期
关键词：
Decanolides; Hydrolytic kinetic resolution; Yamaguchi esterification; Ring-closing metathesis; Epoxides; HYDROLYTIC KINETIC RESOLUTION; EFFICIENT TOTAL-SYNTHESIS; CHOLESTEROL-BIOSYNTHESIS; SECONDARY METABOLITES; TERMINAL EPOXIDES; CONCISE SYNTHESIS; FAMILY; PENICILLIUM; INHIBITORS; LACTONES;
D O I：
10.1016/j.tetlet.2009.10.035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient total synthesis of decarestrictine J has been achieved using ring-closing metathesis and Yamaguchi esterification as key steps. The stereogenic centres were generated by means of iterative hydrolytic kinetic resolution (HKR) of racemic epoxides. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7188 / 7190
页数：3
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