Corpus callosum volume in children with autism

被引:96
作者
Hardan, Antonio Y. [1 ]
Pabalan, Melissa [2 ]
Gupta, Nidhi [1 ]
Bansal, Rahul [3 ]
Melhem, Nadine M. [2 ]
Fedorov, Serguei [3 ]
Keshavan, Matcheri S. [4 ]
Minshew, Nancy J. [2 ]
机构
[1] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[2] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA
[3] Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI USA
[4] Harvard Univ, Sch Med, Dept Psychiat, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
关键词
MRI; White matter; Clinical symptoms; Sensory deficits; WHITE-MATTER; GLUCOSE-METABOLISM; SIZE; INDIVIDUALS; AGENESIS; MORPHOLOGY; CONNECTIVITY; NEUROBIOLOGY; ACTIVATION; DEFICITS;
D O I
10.1016/j.pscychresns.2009.03.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The corpus callosum (CC) is the main commissure connecting the cerebral hemispheres Previous evidence suggests the involvement of the CC in the pathophysiology of autism. However, most studies examined the mid-sagittal area and investigations applying novel methods are warranted. The goal of this investigation is to apply a volumetric method to examine the size of the CC in autism and to identify any association with clinical features. An MRI-based morphometric study of the total CC volume and its seven subdivisions was conducted and involved 22 children with autism (age range 8.1-127 years) and 23 healthy, age-matched controls. Reductions in the total volume of the CC and several of its subdivisions were found in the autism sample. Associations were observed between CC structures and clinical features including social deficits, repetitive behaviors. and sensory abnormalities. Volumetric alterations of the CC observed in this investigation are consistent with midsagittal area tracings of decreased CC size in autism. These findings support the aberrant connectivity hypothesis with possible decrease in interhemispheric communications. (C) 2009 Elsevier Ireland Ltd All rights reserved.
引用
收藏
页码:57 / 61
页数:5
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