PLK-1 Regulation of Asymmetric Cell Division in the Early C. elegans Embryo

被引：7
|
作者：
Kim, Amelia J. [1 ]
Griffin, Erik E. [1 ]
机构：
[1] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 8卷
关键词：
PLK1 (Polo-like Kinase 1); C; elegans; asymmetric cell division (ACD); cell polarity; PAR proteins; POLO-LIKE KINASE; NUCLEAR-ENVELOPE BREAKDOWN; ANTERIOR-POSTERIOR AXIS; PAR PROTEINS; DNA-REPLICATION; MOLECULAR-BASIS; MITOTIC ENTRY; AURORA-A; POLARITY; MEX-5;
D O I：
10.3389/fcell.2020.632253
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
PLK1 is a conserved mitotic kinase that is essential for the entry into and progression through mitosis. In addition to its canonical mitotic functions, recent studies have characterized a critical role for PLK-1 in regulating the polarization and asymmetric division of the one-cell C. elegans embryo. Prior to cell division, PLK-1 regulates both the polarization of the PAR proteins at the cell cortex and the segregation of cell fate determinants in the cytoplasm. Following cell division, PLK-1 is preferentially inherited to one daughter cell where it acts to regulate the timing of centrosome separation and cell division. PLK1 also regulates cell polarity in asymmetrically dividing Drosophila neuroblasts and during mammalian planar cell polarity, suggesting it may act broadly to connect cell polarity and cell cycle mechanisms.
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页数：9
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