Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

被引：39

作者：

Kim, HK

Park, Y

Kim, HN

Choi, BH

Jeong, HG

Lee, DG

Hahm, KS

机构：

[1] Chosun Univ, Res Ctr Proteineous Mat, Kwangju 501759, South Korea

[2] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

[3] Chosun Univ, Dept Biomat, Kwangju 501759, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 22期

关键词：

confocal microscopy; licorice; macromolecule inhibition;

D O I：

10.1023/A:1020900124997

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

beta-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 mug ml(-1) against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that beta-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.

引用

页码：1899 / 1902

页数：4

共 12 条

[1] EFFECTS OF GLYCYRRHIZIN AND GLYCYRRHETINIC ACID ON GROWTH AND MELANOGENESIS IN CULTURED B-16 MELANOMA-CELLS [J].