Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy

被引：23

作者：

Papasavvas, Emmanouil ^{[1
]}

Azzoni, Livio ^{[1
]}

Ross, Brian N. ^{[1
]}

Fair, Matthew ^{[1
]}

Yuan, Zhe ^{[1
]}

Gyampoh, Kwasi ^{[1
]}

Mackiewicz, Agnieszka ^{[1
]}

Sciorillo, Amanda C. ^{[1
]}

Pagliuzza, Amelie ^{[2
]}

Lada, Steven M. ^{[3
,4
]}

Wu, Guoxin ^{[5
]}

Goh, Shih Lin ^{[5
]}

Bahnck-Teets, Carolyn ^{[5
]}

Holder, Daniel J. ^{[5
]}

Zuck, Paul D. ^{[5
]}

Damra, Mohammad ^{[1
]}

Lynn, Kenneth M. ^{[6
]}

Tebas, Pablo ^{[7
]}

Mounzer, Karam ^{[8
]}

Kostman, Jay R. ^{[9
]}

Abdel-Mohsen, Mohamed ^{[1
]}

Richman, Douglas ^{[3
,4
]}

Chomont, Nicolas ^{[2
]}

Howell, Bonnie J. ^{[5
]}

Montaner, Luis J. ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[2] Univ Montreal, Montreal, PQ, Canada

[3] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

[4] Univ Calif San Diego, San Diego, CA 92103 USA

[5] Merck & Co Inc, Kenilworth, NJ USA

[6] Univ Penn Hosp, Presbyterian Hosp, Philadelphia, PA USA

[7] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[8] Philadelphia Field Initiating Grp HIV 1 Trials, Jonathan Lax Immune Disorders Treatment Ctr, Philadelphia, PA USA

[9] Philadelphia Field Initiating Grp HIV 1 Trials, John Bell Hlth Ctr, Philadelphia, PA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 72卷 / 03期

关键词：

HIV latency; IPDA; TILDA; p24; integrated HIV; REPLICATION;

D O I：

10.1093/cid/ciaa809

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.

引用

页码：495 / 498

页数：4

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