Long-term treatment of antiphospholipid syndrome-associated cerebral arterial thromboses with intravenous immunoglobulin: a case report

被引：5

作者：

Arabshahi, B. ^{[1
]}

Thompson, E. D.

Smergel, E. M.

Goldsmith, D. P.

机构：

[1] Drexel Univ, Coll Med, St Christophers Hosp Children, Rheumatol Sect, Philadelphia, PA 19104 USA

[2] Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Radiol, Philadelphia, PA 19104 USA

[3] Ctr Childhood Arthritis & Rheumat Dis, Philadelphia, PA 19104 USA

来源：

CLINICAL RHEUMATOLOGY | 2007年 / 26卷 / 02期

关键词：

antiphospholipid antibody syndrome; child; IVIG; stroke;

D O I：

10.1007/s10067-005-0127-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a now 13-year-old male with trisomy 21, hypothyroidism, and insulin-dependent diabetes who developed acute hemiplegia due to the antiphospholipid antibody syndrome (APS) at age four. The risks of long-term anticoagulation were initially considered to be high; hence, he was treated with monthly infusions of intravenous immunoglobulin (IVIG) at 2 g/kg for 2 years and then every other month for 7 years. Antiphospholipid antibodies were no longer detectable within 6 months and have continued to be negative. There was no clinical deterioration or further changes on magnetic resonance arteriography over 7 years. IVIG may be an alternative therapeutic choice for children with APS who are not candidates for conventional anticoagulation.

引用

页码：251 / 253

页数：3

共 20 条

[1] Catastrophic antiphospholipid syndrome -: Clinical and laboratory features of 50 patients [J].