Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity

被引：26

作者：

Li, Yong-Li ^{[2
]}

Yang, Xian-Wen ^{[1
,2
]}

Li, Su-Mei ^{[1
]}

Tang, Jian ^{[2
]}

Tian, Jun-Mian ^{[2
]}

Peng, Xiao-Yang ^{[2
]}

Huang, Da-Seng ^{[2
]}

Zhang, Wei-Dong ^{[2
,3
]}

机构：

[1] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China

[2] Second Mil Med Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 14期

基金：

中国博士后科学基金;

关键词：

Abies chensiensis; Pinaceae; spirobiflavonoids; larixinol; RAW; 264.7; macrophages; NO; FLAVONOID GLYCOSIDES; AERIAL PARTS; CONSTITUENTS;

D O I：

10.1055/s-0029-1185746

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol (1). The structures of spirobiflavonoids 1-3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol (1) was confirmed by X-ray crystallographic analysis. Compounds 1-3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol (1) showed moderate effects, with an IC50 value of 60.0 mu g/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 mu g/mL.

引用

页码：1534 / 1537

页数：4

共 27 条

[1] AN ANTIMICROBIAL KAEMPFEROL-DIACYL-RHAMNOSIDE FROM PENTACHONDRA-PUMILA
BLOOR, SJ
[J]. PHYTOCHEMISTRY, 1995, 38 (04) : 1033 - 1035
[2] CAI H, 1999, CHIN J APPL ENV BIOL, V5, P103
[3] A FERULIC ACID ESTER OF SUCROSE AND OTHER CONSTITUENTS OF BHESA-PANICULATA
HARRISON, LJ
SIA, GL
SIM, KY
TAN, HTW
CONNOLLY, JD
LAVAUD, C
MASSIOT, G
[J]. PHYTOCHEMISTRY, 1995, 38 (06) : 1497 - 1500
[4] Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity
Li, Yong-Li
Yang, Xian-Wen
Li, Su-Mei
Shen, Yun-Heng
Zeng, Hua-Wu
Liu, Xiao-Hua
Tang, Jian
Zhang, Wei-Dong
[J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (06): : 1065 - 1068
[5] Stilbenes, lignans, and phenols from Abies chensiensis
Li, Yong-Li
Yang, Xian-Wen
Zhang, Wei-Dong
[J]. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2008, 36 (12) : 932 - 934
[6] Acylated flavonol glycosides from leaves of Stenochlaena palustris
Liu, HM
Orjala, J
Sticher, O
Rali, T
[J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01): : 70 - 75
[7] SYNTHESIS AND CHARACTERIZATION OF THE NATURALLY-OCCURRING MONOCYCLIC GAMMA-PYRONE GLUCOSIDES
LOOKER, JH
FISHER, MS
[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY, 1985, 4 (03) : 381 - 392
[8] LV YZ, 1983, ACTA PHARMACOL SIN, V18, P199
[9] C-13 NMR-STUDIES OF FLAVONOIDS .3. NATURALLY OCCURRING FLAVONOID GLYCOSIDES AND THEIR ACYLATED DERIVATIVES
MARKHAM, KR
TERNAI, B
STANLEY, R
GEIGER, H
MABRY, TJ
[J]. TETRAHEDRON, 1978, 34 (09) : 1389 - 1397
[10] CHEMISTRY AND BIOCHEMISTRY OF CHINESE DRUGS .6. CYTO-TOXIC COMPONENTS OF ZINGIBER-ZERUMBET, CURCUMA-ZEDOARIA AND CURCUMA-DOMESTICA
MATTHES, HWD
LUU, B
OURISSON, G
[J]. PHYTOCHEMISTRY, 1980, 19 (12) : 2643 - 2650

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