Role of protease and protease inhibitors in cancer pathogenesis and treatment

被引：116

作者：

Eatemadi, Ali ^{[1
,2
]}

Aiyelabegan, Hammed T. ^{[1
,3
]}

Negahdari, Babak ^{[1
]}

Mazlomi, Mohammad Ali ^{[1
]}

Daraee, Hadis ^{[2
,4
]}

Daraee, Nasim ^{[2
,4
]}

Eatemadi, Razieh ^{[5
]}

Sadroddiny, Esmaeil ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran

[2] Lorestan Univ Med Sci, Sch Med, Dept Med Biotechnol, Lorestan, Iran

[3] TUMS IC, Tehran, Iran

[4] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[5] Univ Ilam, Ilam, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 86卷

关键词：

Protease; Protease inhibitor; cancer; HUMAN PROCATHEPSIN-D; CATHEPSIN-B; STEFIN-A; CYSTEINE CATHEPSINS; PANCREATIC-CANCER; MATRIX METALLOPROTEINASES; EXTRACELLULAR-MATRIX; SERPINS FLEX; CYSTATIN-C; EXPRESSION;

D O I：

10.1016/j.biopha.2016.12.021

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer is the second cause of death in 2015, and it has been estimated to surpass heart diseases as the leading cause of death in the next few years. Several mechanisms are involved in cancer pathogenesis. Studies have indicated that proteases are also implicated in tumor growth and progression which is highly dependent on nutrient and oxygen supply. On the other hand, protease inhibitors could be considered as a potent strategy in cancer therapy. On the basis of the type of the key amino acid in the active site of the protease and the mechanism of peptide bond cleavage, proteases can be classified into six groups: cysteine, serine, threonine, glutamic acid, aspartate proteases, as well as matrix metalloproteases. In this review, we focus on the role of different types of proteases and protease inhibitors in cancer pathogenesis. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：221 / 231

页数：11

共 117 条

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