Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice

被引：48

作者：

Yang, Meilian ^{[1
]}

Wu, Zihuan ^{[1
]}

Wang, Yudan ^{[2
]}

Kai, Guoyin ^{[3
]}

Njateng, Guy Sedar Singor ^{[4
]}

Cai, Shengbao ^{[1
]}

Cao, Jianxin ^{[1
]}

Cheng, Guiguang ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Engn Res Ctr Biopolymer Funct Mat Yunnan, Kunming 650500, Yunnan, Peoples R China

[3] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China

[4] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2019年 / 131卷

基金：

中国国家自然科学基金;

关键词：

Epigynum auritum; Acute and subacute oral toxicities; Hematology; Histopathology; Serum biochemistry analysis; SUBCHRONIC TOXICITY; PREGNANE GLYCOSIDES; ORAL TOXICITY; ANTIOXIDANT; INFUSIONS; FRACTION; PROFILE; PULP;

D O I：

10.1016/j.fct.2019.05.042

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Acute and subacute toxicities of the ethanol extract from Epigynum auritum (EAE) wereperformed by oral administration in pathogen-free mice. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days, while subacute toxicity test was conducted by daily oral administration of EAE at doses of 312, 625, 1250, and 2500 mg/kg for 28 days. Acute toxicity study showed that LD50 of EAE was over 5000 mg/kg. The results of subacute toxicity showed no significant adverse effect of EAE at 312 mg/kg. Moreover, EAE exhibited toxicities to liver, spleen and kidney in mice determined by hematological, serum biochemical and histological analyses during daily oral administration of 1250 mg/kg and 2500 mg/kg EAE. The results revealed that the dose of EAE lower than 625 mg/kg can be regarded as safe.

引用

页数：8

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