Molecular ablation of ventricular tachycardia after myocardial infarction

被引：90

作者：

Sasano, Tetsuo

McDonald, Amy D.

Kikuchi, Kan

Donahue, J. Kevin

机构：

[1] Case Western Reserve Univ, Heart & Vasc Res Ctr, Metrohlth Hosp, Sch Med, Cleveland, OH 44109 USA

[2] Kyushu Kosei Nenkin Hosp, Div Cardiol, Kitakyushu, Fukuoka 8078555, Japan

来源：

NATURE MEDICINE | 2006年 / 12卷 / 11期

关键词：

D O I：

10.1038/nm1503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel ( KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.

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收藏

页码：1256 / 1258

页数：3

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