Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients

被引：18

作者：

Ikeda, Toshiaki ^{[1
]}

Kamohara, Hidenobu ^{[1
]}

Suda, Shingo ^{[1
]}

Nagura, Takeo ^{[1
]}

Tomino, Mikiko ^{[2
]}

Sugi, Masatoshi ^{[2
]}

Wajima, Zen'ichiro ^{[2
]}

机构：

[1] Tokyo Med Univ, Hachioji Med Ctr, Div Crit Care & Emergency Med, Tokyo 1930998, Japan

[2] Tokyo Med Univ, Hachioji Med Ctr, Dept Anesthesiol, Tokyo 1930998, Japan

来源：

BIOMEDICINES | 2019年 / 7卷 / 03期

关键词：

blood endotoxin; endotoxin activity assay (EAA); procalcitonin (PCT); presepsin; interleukin (IL)-6; sepsis; CRITICALLY-ILL PATIENTS; SEPTIC SHOCK; PROCALCITONIN; SEPSIS; PNEUMONIA; DIAGNOSIS; MARKERS; TRAUMA; ASSAY; RISK;

D O I：

10.3390/biomedicines7030047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we concurrently measured the endotoxin activity (EA) level and levels of multiple biomarkers in patient blood obtained within 24 h after being admitted into the intensive care unit (ICU) and analyzed whether there were links between these markers and their associations with patient conditions and outcomes. The EA levels highly correlated with disease severity and patient survival, and showed a significant positive association with levels of lactate, procalcitonin, presepsin, and interleukin-6. Notably, the EA level was the marker that most highly correlated with the results of blood culture, and the presepsin level was the marker most highly correlated with the survival outcome at 28 days. Thus, the optimal biomarker should be selected based on whether it will be used to discriminate the presence of an infection or to predict survival.

引用

页数：12

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