Angiosarcoma of the Breast A Rare Clinicopathological Entity

被引:26
作者
Biswas, Tithi [1 ]
Tang, Ping [2 ]
Muhs, Ann [1 ]
Ling, Marilyn [1 ]
机构
[1] Univ Rochester, Med Ctr, Dept Radiat Oncol, Rochester, NY 14642 USA
[2] Univ Rochester, Med Ctr, Dept Pathol, Rochester, NY 14642 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2009年 / 32卷 / 06期
关键词
angiosarcoma; radiotherapy; breast cancer; breast imaging; CUTANEOUS ANGIOSARCOMA; CONSERVING THERAPY; IRRADIATED BREAST; RADIOTHERAPY; SARCOMA; CANCER; CARCINOMA;
D O I
10.1097/COC.0b013e3181967f09
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: Angiosarcoma is a rare subtype of sarcoma that usually arises after radiation therapy for primary breast cancer. Primary sarcomas of the breast are rare entities and account for less than 1% of all malignant breast neoplasms. We examine our institutional experience with angiosarcomas of the breast that were diagnosed and treated between 1996 and 2007. Methods: To conduct a retrospective review, all female patients with a diagnosis of angiosarcoma of the breast were identified from our pathology database. Their hospital records were retrieved to gather information on treatment, tumor response, failure, and survival. Results: A total of 8 patients were identified who had a histologically confirmed diagnosis of angiosarcoma of the breast. Median age was 70.3 years at diagnosis (range, 35.6-85.7 years). Seven (87%) patients had a history of prior radiation to the breast, whereas 1 (13%) had primary arigiosarcoma. The median overall survival was 37.4 months (8.7-92.8 months) and relapse-free survival was 17.9 months (2.5-69.4 months). Conclusions: Even though angiosarcomas are rare neoplasms, they are increasingly recognized as the result of more breast-conserving therapy. High clinical suspicion and MRI may contribute to early diagnosis but a biopsy is always necessary to confirm it. These tumors tend to behave aggressively and require a multidisciplinary approach to improve the outcome.
引用
收藏
页码:582 / 586
页数:5
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