BNIP3, a cell pro-apoptotic protein, involved in response to viral infection in orange spotted grouper, Epinephelus coioides

被引：5
|
作者：
Cai, Jia [1 ,2 ,3 ]
Wei, Shina
Yu, Dapeng [1 ,2 ,3 ]
Song, Rui [6 ]
Lu, Yishan [1 ,2 ,3 ]
Wu, Zaohe [2 ,3 ]
Qin, Qiwei [4 ,5 ]
Jian, Jichang [1 ,2 ,3 ]
机构：
[1] Guangdong Ocean Univ, Coll Fishery, 1 Haida Rd, Zhanjiang 524088, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524088, Peoples R China
[3] Guangdong Key Lab Control Dis Aquat Econ Anim, Zhanjiang 524088, Peoples R China
[4] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
[5] South China Agr Univ, Coll Marine Sci, Guangzhou 510642, Guangdong, Peoples R China
[6] Hunan Fisheries Sci Inst, Changsha 410153, Hunan, Peoples R China
来源：
FISH & SHELLFISH IMMUNOLOGY | 2017年 / 64卷
基金：
中国国家自然科学基金;
关键词：
Epinephelus coioides; BNIP3; Singapore grouper iridovirus (SGIV); Viral infection; DEATH; IRIDOVIRUS; MITOCHONDRIAL; EXPRESSION; AUTOPHAGY; FISH; NIX; HYPOXIA; STRESS; DOMAIN;
D O I：
10.1016/j.fsi.2017.03.047
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
BNIP3 is a kind of BH3-only protein that induces both cell death and autophagy. Here, a BNIP3 gene (EcBNIP3) was identified from orange spotted grouper, Epinephelus coioides. EcBNIP3 possessed 236 amino acids residues, contained a conservative BNIP3 domain and a transmembrane region. Besides, EcBNIP3 expressed at a relative high level in heart and spleen. EcBNIP3 transcript was up-regulated after SGIV infection in vitro. Subcellular localization analysis revealed that EcBNIP3 was predominantly localized in the cytoplasm and co-localized with mitochondria. In addition, overexpression EcBNIP3 accelerated SGIV infection induced cell death but inhibited viral genes transcription. Taken together, these results provided new evidence that fish BNIP3 might involved in response to virus infection. (C) 2017 Published by Elsevier Ltd.
引用
收藏
页码：407 / 413
页数：7
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