Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa

被引：113
作者：
de Vos, Willem M. [1 ,2 ]
机构：
[1] Wageningen Univ, Lab Microbiol, Wageningen, Netherlands
[2] Univ Helsinki, Immunobiol Res Program, Helsinki, Finland
来源：
MICROBIOLOGY-SGM | 2017年 / 163卷 / 05期
基金：
芬兰科学院; 欧洲研究理事会;
关键词：
microbe profile;
D O I：
10.1099/mic.0.000444
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Akkermansia muciniphila is an abundant inhabitant of the intestinal tract of humans and many other animals. It is the sole intestinal representative of the verrucomicrobia in human stools and depleted in adults suffering from obesity, diabetes and several other diseases. A. muciniphila degrades intestinal mucin into mainly propionic and acetic acid, and lives in symbiosis with its host, marked by signalling to immune and metabolic pathways, priming trophic chains and likely providing competitive exclusion at the host-microbe interface. Since its recent discovery, A. muciniphila has increasingly been studied and recognized as a true intestinal symbiont promoting beneficial interactions in the intestinal tract.
引用
收藏
页码：646 / 648
页数：3
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