The immunopathogenesis of oral lichen planus-Is there a role for mucosal associated invariant T cells?

被引：49

作者：

DeAngelis, Lara M. ^{[1
]}

Cirillo, Nicola ^{[1
]}

McCullough, Michael J. ^{[1
]}

机构：

[1] Univ Melbourne, Melbourne Dent Sch, Fac Med Dent & Hlth Sci, Carlton, Vic, Australia

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2019年 / 48卷 / 07期

关键词：

immunology; oral lichen planus; pathogenesis; T lymphocytes; MAIT CELLS; ANTIMICROBIAL ACTIVITY; LANGERHANS CELLS; PATHOGENESIS; MACROPHAGES; RECEPTORS; CARRIAGE; LESIONS; SERUM;

D O I：

10.1111/jop.12898

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Oral lichen planus (OLP) is a chronic, T-cell-mediated, immune condition of unknown cause. OLP may present with painful symptoms requiring treatment, as well as lesions outside the oral cavity. It is likely that what initiates the OLP disease process is a complex interaction of host susceptibility and environmental triggers. While it is possible that OLP represents a true autoimmune condition against an epithelial autoantigen, the mechanisms that lead to this immune dysregulation are still poorly understood. In this review article, we discuss current concepts relating to the immunopathogenesis of OLP, as well as the potential contributory roles the oral microbiota and mucosal-associated invariant T (MAIT) cells.

引用

页码：552 / 559

页数：8

共 52 条

[1] Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus [J].

Adami, Guy R. ;

Yeung, Alexander C. F. ;

Stucki, Grant ;

Kolokythas, Antonia ;

Sroussi, Herve Y. ;

Cabay, Robert J. ;

Kuzin, Igor ;

Schwartz, Joel L. .

ARCHIVES OF ORAL BIOLOGY, 2014, 59 (03) :354-361

[2] Phenotypic variability and therapeutic implications of Candida species in patients with oral lichen planus [J].

Arora, S. ;

Verma, M. ;

Gupta, S. R. ;

Urs, A. B. ;

Dhakad, M. S. ;

Kaur, R. .

BIOTECHNIC & HISTOCHEMISTRY, 2016, 91 (04) :237-241

[3] ORAL LICHEN-PLANUS - A DEMOGRAPHIC-STUDY [J].

AXELL, T ;

RUNDQUIST, L .

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY, 1987, 15 (01) :52-56

[4]

AXELL T, 1976, ODONTOL REVY, V27, P1

[5] Immunoexpression of Interleukin-22 and Interleukin-23 in Oral and Cutaneous Lichen Planus Lesions: A Preliminary Study [J].

Chen, Jun ;

Feng, Jinqiu ;

Chen, Xiangdong ;

Xu, Hui ;

Zhou, Zengtong ;

Shen, Xuemin ;

Bao, Zhexuan ;

Liu, Wei ;

Shen, Zhengyu .

MEDIATORS OF INFLAMMATION, 2013, 2013

[6] MAIT cells and pathogen defense [J].

Cowley, Siobhan C. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (24) :4831-4840

[7] Oral lichen planus: immunohistology of mucosal lesions [J].

Dorrego, MV ;

Correnti, M ;

Delgado, R ;

Tapia, FJ .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2002, 31 (07) :410-414

[8] Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells [J].

Dusseaux, Mathilde ;

Martin, Emmanuel ;

Serriari, Nacer ;

Peguillet, Isabelle ;

Premel, Virginie ;

Louis, Delphine ;

Milder, Maud ;

Le Bourhis, Lionel ;

Soudais, Claire ;

Treiner, Emmanuel ;

Lantz, Olivier .

BLOOD, 2011, 117 (04) :1250-1259

[9] MAITcells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation [J].

Gibbs, A. ;

Leeansyah, E. ;

Introini, A. ;

Paquin-Proulx, D. ;

Hasselrot, K. ;

Andersson, E. ;

Broliden, K. ;

Sandberg, J. K. ;

Tjernlund, A. .

MUCOSAL IMMUNOLOGY, 2017, 10 (01) :35-45

[10] MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage [J].

Gold, Marielle C. ;

McLaren, James E. ;

Reistetter, Joseph A. ;

Smyk-Pearson, Sue ;

Ladell, Kristin ;

Swarbrick, Gwendolyn M. ;

Yu, Yik Y. L. ;

Hansen, Ted H. ;

Lund, Ole ;

Nielsen, Morten ;

Gerritsen, Bram ;

Kesmir, Can ;

Miles, John J. ;

Lewinsohn, Deborah A. ;

Price, David A. ;

Lewinsohn, David M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (08) :1601-1610

← 1 2 3 4 5 6 →