New polyene macrolide antibiotics from Streptomyces sp M90025

被引：0

作者：

Seo, Y ^{[1
]}

Cho, KW ^{[1
]}

Lee, HS ^{[1
]}

Yoon, TM ^{[1
]}

Shin, JH ^{[1
]}

机构：

[1] Korea Ocean Res & Dev Inst, Marine Nat Prod Lab, Ansan 425600, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2000年 / 10卷 / 02期

关键词：

polyene antibiotics; 28-membered macrolides; Streptomyces; elizabethin;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three polyene macrolide antibiotics including two new compounds were isolated from the culture mycelia of a Streptomyces species. The structures of these metabolites were determined as elizabethin, a previously reported 28-membered macrolide and two analogs, using combined spectroscopic methods. These compounds exhibited antifungal activity and cytotoxicity against a human leukemia cell.

引用

页码：176 / 180

页数：5

共 11 条

[1]

[Anonymous], INTERPRETATION ULTRA

[2] ANTIBIOTICS FROM THE NEWLY ISOLATED STREPTOMYCES-ELIZABETHII .2. ISOLATION AND CHARACTERIZATION OF THE ANTIBIOTICS [J].

BIRD, CW ;

LATIF, M .

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 1981, 31 (06) :368-370

[3]

HOLZ RW, 1979, ANTIBIOTICS 2, V5, P313

[4]

LOCCI R, 1994, BERGEYS MANUAL SYSTE, P2451

[5] BIOSYNTHESIS AND FULL NMR ASSIGNMENT OF FUNGICHROMIN, A POLYENE ANTIBIOTIC FROM STREPTOMYCES-CELLULOSAE [J].

NOGUCHI, H ;

HARRISON, PH ;

ARAI, K ;

NAKASHIMA, TT ;

TRIMBLE, LA ;

VEDERAS, JC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (09) :2938-2945

[6] PHYSICOCHEMICAL AND BIOLOGICAL COMPARISON OF POLYENE MACROLIDE ANTIBIOTICS FUNGICHROMIN, LAGOSIN AND COGOMYCIN [J].

PANDEY, RC ;

GUENTHER, EC ;

ASZALOS, AA ;

BRAJTBURG, J .

JOURNAL OF ANTIBIOTICS, 1982, 35 (08) :988-996

[7] ANTIBIOTICS FROM THE NEWLY ISOLATED STREPTOMYCES-ELIZABETHII .1. PRODUCTION OF A POLYENE ANTIFUNGAL AGENT (ELIZABETHIN) AND ACTINOMYCIN IN SHAKE FLASK CULTURES [J].

PIRT, SJ ;

PICKETT, MA ;

PICKETT, AM ;

VANDAMME, EJ ;

BIRD, CW .

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 1981, 31 (03) :167-177

[8]

QUESNEL LB, 1990, COMPREHENSIVE MED CH, V2, P114

[9] Total synthesis of filipin III [J].

Richardson, TI ;

Rychnovsky, SD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (50) :12360-12361

[10] Two-dimensional NMR analysis of acetonide derivatives in the stereochemical assignment of polyol chains: The absolute configurations of dermostatins A and B [J].

Rychnovsky, SD ;

Richardson, TI ;

Rogers, BN .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (09) :2925-2934

← 1 2 →