Crystalline salicylic acid as an efficient catalyst for ultrafast Paal-Knorr pyrrole synthesis under microwave induction

被引：9
作者：
Aghapoor, Kioumars [1 ]
Mohsenzadeh, Farshid [1 ]
Darabi, Hossein Reza [1 ]
Sayahi, Hani [1 ]
机构：
[1] Chem & Chem Engn Res Ctr Iran, Appl Chem Synth Lab, Pajoohesh Blvd,Km 17, Tehran 1496813151, Iran
来源：
JOURNAL OF CHEMICAL SCIENCES | 2021年 / 133卷 / 02期
基金：
英国科研创新办公室;
关键词：
Salicylic acid and microwaves; Organocatalysis; Paal-Knorr reaction; 2,5-dimethylpyrrole; SOLVENT-FREE; SUBSTITUTED PYRROLES; ASSISTED SYNTHESIS; POTENT INHIBITORS; MOLECULAR DOCKING; GREEN; DERIVATIVES; ORGANOCATALYSIS; FEATURES; DESIGN;
D O I：
10.1007/s12039-021-01891-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids as organocatalysts has been investigated for solvent-free Paal-Knorr pyrrole synthesis under microwave activation. Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst because its efficiency remained high even under low microwave power irradiation or a shorter reaction time for the model reaction. The outstanding catalytic activity of salicylic acid allowed the Paal-Knorr cyclocondensation with a turnover frequency up to 1472 h(-1) which is unique in the context of a metal-free homogeneous catalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with no risk of metal contamination.
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页数：8
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