Use of antidepressants and risks of restless legs syndrome in patients with irritable bowel syndrome: A population-based cohort study

被引:4
作者
Hsu, Yung-Chu [1 ]
Yang, Hsin-Yi [2 ]
Huang, Wan-Ting [2 ]
Chen, Solomon Chih-Cheng [3 ,4 ]
Lee, Herng-Sheng [5 ]
机构
[1] Chia Yi Christian Hosp, Dept Internal Med, Div Neurol, Ditmanson Med Fdn, Chiayi, Taiwan
[2] Chia Yi Christian Hosp, Clin Med Res Ctr, Ditmanson Med Fdn, Chiayi, Taiwan
[3] Taipei Med Univ, Coll Med, Sch Med, Dept Pediat, Taipei, Taiwan
[4] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Pediat, Kaohsiung, Taiwan
[5] Kaohsiung Vet Gen Hosp, Dept Pathol & Lab Med, Kaohsiung, Taiwan
关键词
DOPAMINE NEURONS; ASSOCIATION; PREVALENCE; EPIDEMIOLOGY; SEROTONIN; MOVEMENTS; ADULTS;
D O I
10.1371/journal.pone.0220641
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Previous research has suggested an association between antidepressants use and clinical restless legs syndrome (RLS) in patients, but there has never been a single study investigating the risk of RLS in irritable bowel syndrome (IBS) patients treated with antidepressants. Hence, we aimed to explore the association between IBS and RLS and to examine the risk of RLS in IBS patients treated with antidepressants. With the use of the National Health Insurance Research Database of Taiwan, 27,437 adults aged. 20 years with newly diagnosed IBS (ICD-9-CM Code 564.1) and gender-and age-matched 54,874 controls without IBS were enrolled between 2000 and 2012. All patients were followed-up until RLS diagnosis, withdrawal from the National Health Insurance program, or end of 2013. We used the Cox proportional hazards model to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) of RLS. RLS was more prevalent in IBS patients than in the non-IBS group (7.57 versus 3.36 per 10,000 person-years), with an increased risk of RLS (adjusted HR [aHR], 1.91; 95% CI, 1.52-2.40). Multivariate Cox proportional hazards analysis identified older age (age, 51-65 years; aHR, 1.67; 95% CI, 1.09-2.56; and age > 65; aHR, 1.59; 95% CI, 1.02-2.48), hypothyroidism (aHR, 4.24; 95% CI, 1.92-9.37), CAD (aHR, 1.70; 95% CI, 1.17-2.48), and depression (aHR, 3.15; 95% CI, 2.14-4.64) as independent RLS risk factors in IBS patients. In addition, the male SSRIs users were associated with significantly higher risk of RLS (aHR, 3.05 95% CI, 1.34-6.92). Our study showed that the IBS group has higher risk of RLS. Moreover, SSRIs use may increase the risk of RLS in male IBS patients.
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页数:13
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