Mechanistic Studies on the Reaction between R2N-NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl Group from R2N-NONOates to Cobalt(III) Centers

被引：36

作者：

Hassanin, Hanaa A. ^{[1
,2
,3
]}

Hannibal, Luciana ^{[4
,5
]}

Jacobsen, Donald W. ^{[4
,5
]}

El-Shahat, Mohamed F. ^{[3
]}

Hamza, Mohamed S. A. ^{[3
]}

Brasch, Nicola E. ^{[1
,2
]}

机构：

[1] Kent State Univ, Dept Chem, Kent, OH 44242 USA

[2] Kent State Univ, Sch Biomed Sci, Kent, OH 44242 USA

[3] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt

[4] Kent State Univ, Sch Biomed Sci, Kent, OH 44242 USA

[5] Cleveland Clin, Lerner Res Inst, Dept Cell Biol, Cleveland, OH 44195 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 47期

基金：

美国国家科学基金会;

关键词：

cobalamins; kinetics; nitroxyl complexes; N; O ligands; vitamins; NITRIC-OXIDE RELEASE; ANTILEUKEMIC ACTIVITY; ANTICANCER LEAD; NO; COMPLEXES; CHEMISTRY; KINETICS; PRODRUGS; ANALOGS; BINDING;

D O I：

10.1002/anie.200904360

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tales of the unexpected: Transfer of a nitroxyl group from R2N-NONOates to aquacobalamin to form nitroxylcobaiamin does not proceed via H+-catalyzed R2NNONOate decomposition, but instead occurs via a probable NONOate-cobalamin intermediate (see scheme; r.d.s.=rate-determining step). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8909 / 8913

页数：5

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