Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine

被引：38

作者：

Liu, Ye ^{[1
,2
]}

Balachandran, Yekkuni L. ^{[1
,2
]}

Li, Dan ^{[3
]}

Shao, Yiming ^{[3
,4
,5
,6
]}

Jiang, Xingyu ^{[1
,2
]}

机构：

[1] Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China

[2] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Beijing 100190, Peoples R China

[4] Peking Univ, Ctr Infect Dis, Beijing 100190, Peoples R China

[5] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310027, Zhejiang, Peoples R China

[6] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

来源：

ACS NANO | 2016年 / 10卷 / 03期

基金：

中国国家自然科学基金;

关键词：

silver nanorod; HIV vaccine; noncarrier adjuvant; polyvinylpyrrolidone; poly(ethylene glycol); immune response; T-CELLS; CELLULAR UPTAKE; NANOPARTICLES; TOXICITY; RECEPTORS; EFFICACY; ANTIGEN; FUTURE; HELPER;

D O I：

10.1021/acsnano.5b08025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One of the biggest obstacles for the development of HIV vaccines is how to sufficiently trigger crucial anti-HIV immunities via a safe manner. We herein integrated surface modification-dependent immunostimulation against HIV vaccine and shape-dependent biosafety and designed a safe noncarrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Such silver nanorods can significantly elevate crucial immunities of HIV vaccine and overcome the toxicity, which is a big problem for other existing adjuvants. This study thus provided a principle for designing a safe and high-efficacy material for an adjuvant and allow researchers to really have a safe and effective prophylaxis against HIV. We expect this material approach to be applicable to other types of vaccines, whether they are preventative or therapeutic.

引用

页码：3589 / 3596

页数：8

共 39 条

[1] Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles [J].