Severe insulin resistance associated with subcutaneous amyloid deposition

被引：46

作者：

Albert, Stewart G.

Obadiah, Joseph

Parseghian, Shant A.

Hurley, M. Yadira

Mooradian, Arshag D.

机构：

[1] St Louis Univ, Sch Med, Dept Internal Med, Div Endocrinol, St Louis, MO 63104 USA

[2] St Louis Univ, Sch Med, Dept Dermatol, St Louis, MO 63104 USA

[3] Univ Florida, Dept Internal Med, Jacksonville, FL 32209 USA

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2007年 / 75卷 / 03期

关键词：

insulin resistance; amyloid; insulin-degrading enzyme;

D O I：

10.1016/j.diabres.2006.07.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 59-year-old man with type I diabetes mellitus presented with severe resistance to subcutaneously injected insulin. Histological analysis of the injection sites, demonstrated foreign body type granulomas surrounding areas of amyloidosis. It is suggested that the granulomas were the source of an insulin-degrading enzyme (IDE) which simultaneously degraded amyloidogenic precursors into localized amyloid deposits. These findings may add insight into the role of insulin-degrading enzymes in the etiology of subcutaneous insulin resistance syndromes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：374 / 376

页数：3

共 7 条

[1] An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures [J].