Experimental cutaneous Bacillus anthracis infections in hairless HRS/J mice

被引:8
|
作者
Bischof, Timothy S.
Hahn, Beth L.
Sohnle, Peter G. [2 ]
机构
[1] Vet Adm Med Ctr, Consultant Care Div, Milwaukee, WI 53295 USA
[2] Vet Adm Med Ctr, Res Serv, Milwaukee, WI 53295 USA
[3] Med Coll Wisconsin, Dept Med, Div Infect Dis, Milwaukee, WI 53226 USA
关键词
anthrax; Bacillus anthracis; hair follicles; hairless mice; neutrophils;
D O I
10.1111/j.1365-2613.2006.00519.x
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Previous studies of experimental Bacillus anthracis cutaneous infections in mice have implicated hair follicles as a likely entry site. Hairless HRS/J mice were used to investigate this possibility because of their non-functional hair follicles that lack penetrating hair shafts. These mice also have diminished macrophage function, increased susceptibility to Listeria, and enhanced neutrophil responses. HRS/J and Balb/c mice were found to be resistant to epicutaneous inoculation with Bacillus anthracis (Sterne) spores onto abraded skin when compared with DBA/2 mice or leucopenic C57BL/6 mice. The HRS/J mice also resisted spore injections that bypassed hair follicles. Haired HRS/J heterozygote mice demonstrated similar reduced susceptibility to B. anthracis spores. Hairless HRS/J mice that were made leucopenic did become susceptible to the epicutaneous spore inoculations. Histologically, the hairless and haired HRS/J mice showed markedly reduced numbers of organisms in hair follicles and the interfollicular dermis when compared even with the resistant Balb/c mice; inflammatory cell infiltrates in the superficial dermis were increased in the HRS/J mice compared with more sensitive strains. Therefore, resistance in the HRS/J mice was apparent at the initial site of epicutaneous inoculation and seemed related to an accumulation of dermal neutrophils rather than to a lack of functional hair follicles.
引用
收藏
页码:75 / 84
页数:10
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